Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

Crystallographic fragment screening is a powerful methodology that enables the identification of low molecular weight ligands and has shown great promises in drug discovery. In this work we report the results of a fragment screening carried out in an effort to further map the cavities of trypanothio...

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Bibliographic Details
Main Authors: Cécile Exertier, Lorenzo Antonelli, Vittorio Brufani, Gianni Colotti, Andrea Ilari, Annarita Fiorillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Chemical Biology
Subjects:
trypanothione reductase
fragment screening
protein crystallography
surface plasmon resonance
drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fchbi.2025.1605579/full
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