A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form
A validated RP HPLC method for the estimation of atazanavir in capsule dosage form on YMC ODS 150 × 4.6 mm, 5 μ column using mobile phase composition of ammonium dihydrogen phosphate buffer (pH 2.5) with acetonitrile (55:45 v/v). Flow rate was maintained at 1.5 mL/min with 288 nm UV detection. The r...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/812879 |
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| author | K. Srinivasu J. Venkateswara Rao N. Appala Raju K. Mukkanti |
| author_facet | K. Srinivasu J. Venkateswara Rao N. Appala Raju K. Mukkanti |
| author_sort | K. Srinivasu |
| collection | DOAJ |
| description | A validated RP HPLC method for the estimation of atazanavir in capsule dosage form on YMC ODS 150 × 4.6 mm, 5 μ column using mobile phase composition of ammonium dihydrogen phosphate buffer (pH 2.5) with acetonitrile (55:45 v/v). Flow rate was maintained at 1.5 mL/min with 288 nm UV detection. The retention time obtained for atazanavir was at 4.7 min. The detector response was linear in the concentration range of 30 - 600 μg/mL. This method has been validated and shown to be specific, sensitive, precise, linear, accurate, rugged, robust and fast. Hence, this method can be applied for routine quality control of atazanavir in capsule dosage forms as well as in bulk drug. |
| format | Article |
| id | doaj-art-5c3d355c135b44d0ab735eec03254a7e |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-5c3d355c135b44d0ab735eec03254a7e2025-08-20T02:05:42ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018145345610.1155/2011/812879A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage FormK. Srinivasu0J. Venkateswara Rao1N. Appala Raju2K. Mukkanti3ARD, Reddy Labs, Hyderabad, IndiaDepartment of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaDepartment of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaCenter for pharmaceutical sciences, JNT University, Hyderabad, IndiaA validated RP HPLC method for the estimation of atazanavir in capsule dosage form on YMC ODS 150 × 4.6 mm, 5 μ column using mobile phase composition of ammonium dihydrogen phosphate buffer (pH 2.5) with acetonitrile (55:45 v/v). Flow rate was maintained at 1.5 mL/min with 288 nm UV detection. The retention time obtained for atazanavir was at 4.7 min. The detector response was linear in the concentration range of 30 - 600 μg/mL. This method has been validated and shown to be specific, sensitive, precise, linear, accurate, rugged, robust and fast. Hence, this method can be applied for routine quality control of atazanavir in capsule dosage forms as well as in bulk drug.http://dx.doi.org/10.1155/2011/812879 |
| spellingShingle | K. Srinivasu J. Venkateswara Rao N. Appala Raju K. Mukkanti A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form E-Journal of Chemistry |
| title | A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form |
| title_full | A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form |
| title_fullStr | A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form |
| title_full_unstemmed | A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form |
| title_short | A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form |
| title_sort | validated rp hplc method for the determination of atazanavir in pharmaceutical dosage form |
| url | http://dx.doi.org/10.1155/2011/812879 |
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