Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection.
Natural killer cells (NKs) found during pregnancy at the maternal-fetal interface named decidual (d)NKs, show signs of education following first pregnancy, resulting in better placentation and fetus-growth, hence termed pregnancy trained dNKs (PTdNKs). Here we show that PTdNKs provide increased prot...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1011923 |
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| author | Rebecca Kotzur Shira Kahlon Batya Isaacson Moriya Gamliel Yoav Charpak-Amikam Judy Lieberman Gilad Bachrach Debra Goldman-Wohl Simcha Yagel Ofer Beharier Ofer Mandelboim |
| author_facet | Rebecca Kotzur Shira Kahlon Batya Isaacson Moriya Gamliel Yoav Charpak-Amikam Judy Lieberman Gilad Bachrach Debra Goldman-Wohl Simcha Yagel Ofer Beharier Ofer Mandelboim |
| author_sort | Rebecca Kotzur |
| collection | DOAJ |
| description | Natural killer cells (NKs) found during pregnancy at the maternal-fetal interface named decidual (d)NKs, show signs of education following first pregnancy, resulting in better placentation and fetus-growth, hence termed pregnancy trained dNKs (PTdNKs). Here we show that PTdNKs provide increased protection of the fetus from Fusobacterium nucleatum (FN) infection. We demonstrate that PTdNKs secrete elevated amounts of the bacteriocidal protein granulysin (GNLY) upon incubation with FN compared to dNKs derived from first pregnancies, which leads to increased killing of FN. Furthermore, we showed mechanistically that the GNLY secretion is mediated through the interaction of the FN's Fap2 protein with Gal-GalNAc present on PTdNKs. Finally, we show in vivo, using GNLY-tg mice that enhanced protection of the fetuses from FN infection is observed, as compared to wild type and that this enhance protection is NK cell dependent. Altogether, we show a new function for PTdNKs as protectors of the fetus from bacterial infection. |
| format | Article |
| id | doaj-art-5c3bbb7d66694b8dad23a0761ddb0b9d |
| institution | OA Journals |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-5c3bbb7d66694b8dad23a0761ddb0b9d2025-08-20T02:11:38ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-01-01201e101192310.1371/journal.ppat.1011923Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection.Rebecca KotzurShira KahlonBatya IsaacsonMoriya GamlielYoav Charpak-AmikamJudy LiebermanGilad BachrachDebra Goldman-WohlSimcha YagelOfer BeharierOfer MandelboimNatural killer cells (NKs) found during pregnancy at the maternal-fetal interface named decidual (d)NKs, show signs of education following first pregnancy, resulting in better placentation and fetus-growth, hence termed pregnancy trained dNKs (PTdNKs). Here we show that PTdNKs provide increased protection of the fetus from Fusobacterium nucleatum (FN) infection. We demonstrate that PTdNKs secrete elevated amounts of the bacteriocidal protein granulysin (GNLY) upon incubation with FN compared to dNKs derived from first pregnancies, which leads to increased killing of FN. Furthermore, we showed mechanistically that the GNLY secretion is mediated through the interaction of the FN's Fap2 protein with Gal-GalNAc present on PTdNKs. Finally, we show in vivo, using GNLY-tg mice that enhanced protection of the fetuses from FN infection is observed, as compared to wild type and that this enhance protection is NK cell dependent. Altogether, we show a new function for PTdNKs as protectors of the fetus from bacterial infection.https://doi.org/10.1371/journal.ppat.1011923 |
| spellingShingle | Rebecca Kotzur Shira Kahlon Batya Isaacson Moriya Gamliel Yoav Charpak-Amikam Judy Lieberman Gilad Bachrach Debra Goldman-Wohl Simcha Yagel Ofer Beharier Ofer Mandelboim Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection. PLoS Pathogens |
| title | Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection. |
| title_full | Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection. |
| title_fullStr | Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection. |
| title_full_unstemmed | Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection. |
| title_short | Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection. |
| title_sort | pregnancy trained decidual nk cells protect pregnancies from harmful fusobacterium nucleatum infection |
| url | https://doi.org/10.1371/journal.ppat.1011923 |
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