Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study
Abstract Background The Anticholinergic Risk Scale and Total Anticholinergic Load were developed to assess the risks associated with anticholinergic drugs. Recently, the Japan Anticholinergic Risk Scale was introduced; however, the total anticholinergic load for adverse events has not been clarified...
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BMC
2025-01-01
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| Series: | Journal of Pharmaceutical Health Care and Sciences |
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| Online Access: | https://doi.org/10.1186/s40780-025-00413-w |
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| author | Yusuke Kan Maki Doi Yoshihiro Uesawa |
| author_facet | Yusuke Kan Maki Doi Yoshihiro Uesawa |
| author_sort | Yusuke Kan |
| collection | DOAJ |
| description | Abstract Background The Anticholinergic Risk Scale and Total Anticholinergic Load were developed to assess the risks associated with anticholinergic drugs. Recently, the Japan Anticholinergic Risk Scale was introduced; however, the total anticholinergic load for adverse events has not been clarified, and the criteria for risk assessment in clinical practice have not been established. In this study, we used data from the Japanese Adverse Drug Event Report (JADER) database provided by the Pharmaceuticals and Medical Devices Agency to determine the total anticholinergic load associated with reported adverse events related to anticholinergic syndrome. Methods Using JADER data from April 2004 to September 2023, we investigated the association between drugs included in the J-ARS and adverse events related to anticholinergic syndrome. In addition, we calculated the total anticholinergic load for each case involving a drug recorded in the JADER database and compared it with other adverse events associated with anticholinergic effects. Results Based on the JADER data, we observed an association between anticholinergic syndrome-related adverse events and the drugs listed in the J-ARS, confirming the feasibility of calculating the total anticholinergic drug burden for each case. In the group reporting anticholinergic syndrome–related adverse events, the mean ± standard deviation of the total anticholinergic load was 4.20 ± 3.09. Conclusions The mean total anticholinergic load of anticholinergic syndrome-related adverse events obtained from the JADER database in this study supports the development of a comprehensive risk assessment of anticholinergic drugs in clinical practice. |
| format | Article |
| id | doaj-art-5c3ad4bcb1e9400882ede04d4966826f |
| institution | Kabale University |
| issn | 2055-0294 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Pharmaceutical Health Care and Sciences |
| spelling | doaj-art-5c3ad4bcb1e9400882ede04d4966826f2025-02-02T12:34:51ZengBMCJournal of Pharmaceutical Health Care and Sciences2055-02942025-01-011111810.1186/s40780-025-00413-wInvestigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance studyYusuke Kan0Maki Doi1Yoshihiro Uesawa2Nanohana Pharmacy, Nanohana Hokkaido, IncDepartment of Academics, Medical System Network, IncDepartment of Medical Molecular Informatics, Meiji Pharmaceutical UniversityAbstract Background The Anticholinergic Risk Scale and Total Anticholinergic Load were developed to assess the risks associated with anticholinergic drugs. Recently, the Japan Anticholinergic Risk Scale was introduced; however, the total anticholinergic load for adverse events has not been clarified, and the criteria for risk assessment in clinical practice have not been established. In this study, we used data from the Japanese Adverse Drug Event Report (JADER) database provided by the Pharmaceuticals and Medical Devices Agency to determine the total anticholinergic load associated with reported adverse events related to anticholinergic syndrome. Methods Using JADER data from April 2004 to September 2023, we investigated the association between drugs included in the J-ARS and adverse events related to anticholinergic syndrome. In addition, we calculated the total anticholinergic load for each case involving a drug recorded in the JADER database and compared it with other adverse events associated with anticholinergic effects. Results Based on the JADER data, we observed an association between anticholinergic syndrome-related adverse events and the drugs listed in the J-ARS, confirming the feasibility of calculating the total anticholinergic drug burden for each case. In the group reporting anticholinergic syndrome–related adverse events, the mean ± standard deviation of the total anticholinergic load was 4.20 ± 3.09. Conclusions The mean total anticholinergic load of anticholinergic syndrome-related adverse events obtained from the JADER database in this study supports the development of a comprehensive risk assessment of anticholinergic drugs in clinical practice.https://doi.org/10.1186/s40780-025-00413-wJADERJapan anticholinergic risk scaleTotal anticholinergic loadAnticholinergic syndrome |
| spellingShingle | Yusuke Kan Maki Doi Yoshihiro Uesawa Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study Journal of Pharmaceutical Health Care and Sciences JADER Japan anticholinergic risk scale Total anticholinergic load Anticholinergic syndrome |
| title | Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study |
| title_full | Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study |
| title_fullStr | Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study |
| title_full_unstemmed | Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study |
| title_short | Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study |
| title_sort | investigation of the total anticholinergic load of reported anticholinergic drug related adverse events using the japanese adverse drug event report database a retrospective pharmacovigilance study |
| topic | JADER Japan anticholinergic risk scale Total anticholinergic load Anticholinergic syndrome |
| url | https://doi.org/10.1186/s40780-025-00413-w |
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