Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage
Aim of investigation. To determine diagnostic value of procalcitonin (PCT) and C-reactive protein (CRP) at anastomotic leakage (AL) following lower anterior resection (LAR) of the rectum. Material and methods. Overall 100 patients underwent surgery for epithelial tumors of rectum in the period 2013-...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2018-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860282623000576 |
|---|---|
| author | Yu. A. Shelygin M. A. Tarasov M. A. Sukhina I. V. Zarodnyuk Ye. G. Rybakov |
| author_facet | Yu. A. Shelygin M. A. Tarasov M. A. Sukhina I. V. Zarodnyuk Ye. G. Rybakov |
| author_sort | Yu. A. Shelygin |
| collection | DOAJ |
| description | Aim of investigation. To determine diagnostic value of procalcitonin (PCT) and C-reactive protein (CRP) at anastomotic leakage (AL) following lower anterior resection (LAR) of the rectum. Material and methods. Overall 100 patients underwent surgery for epithelial tumors of rectum in the period 2013-2016 yy in the volume of LAR with the formation of anastomosis and preventive stoma. In patients without clinical symptoms radiopaque study was performed in order to identify asymptomatic AL on day 7 after the surgery. AL rate, difference in PCT and CRP levels in patients with AL and consistent anastomosis were assessed along with sensitivity, specificity, positive and negative predictive value of these markers. Results. AL was diagnosed in 20% (20 of 100) of patients: in 11% (11 of 100) - with clinical manifestations, in 9% (9 of 100) - without clinical symptoms (contrast leakage according to X-ray study). In the group of patients with anastomotic leak, the median of C-reactive protein level differed from that in patients with uncompromised integrity of anastomosis at 3rd day after surgery (156 mg/L vs 81 mg/L, respectively - t-test, p=0.0004) and postoperative day 6 (136 mg/L vs. 52 mg/L, respectively - t-test, p |
| format | Article |
| id | doaj-art-5c29be45f31d4a33b2288edf7b0fb56f |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-5c29be45f31d4a33b2288edf7b0fb56f2025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-012719310010.22416/1382-4376-2017-27-1-93-100127Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakageYu. A. Shelygin0M. A. Tarasov1M. A. Sukhina2I. V. Zarodnyuk3Ye. G. Rybakov4Federal government-financed institution «Ryzhikh State Scientific Center of Coloproctology»; Federal State Budgetary Educational Institution of Additional Professional Education «Russian Academy of Postgraduate Medical Education»Federal government-financed institution «Ryzhikh State Scientific Center of Coloproctology»Federal government-financed institution «Ryzhikh State Scientific Center of Coloproctology»Federal government-financed institution «Ryzhikh State Scientific Center of Coloproctology»Federal government-financed institution «Ryzhikh State Scientific Center of Coloproctology»Aim of investigation. To determine diagnostic value of procalcitonin (PCT) and C-reactive protein (CRP) at anastomotic leakage (AL) following lower anterior resection (LAR) of the rectum. Material and methods. Overall 100 patients underwent surgery for epithelial tumors of rectum in the period 2013-2016 yy in the volume of LAR with the formation of anastomosis and preventive stoma. In patients without clinical symptoms radiopaque study was performed in order to identify asymptomatic AL on day 7 after the surgery. AL rate, difference in PCT and CRP levels in patients with AL and consistent anastomosis were assessed along with sensitivity, specificity, positive and negative predictive value of these markers. Results. AL was diagnosed in 20% (20 of 100) of patients: in 11% (11 of 100) - with clinical manifestations, in 9% (9 of 100) - without clinical symptoms (contrast leakage according to X-ray study). In the group of patients with anastomotic leak, the median of C-reactive protein level differed from that in patients with uncompromised integrity of anastomosis at 3rd day after surgery (156 mg/L vs 81 mg/L, respectively - t-test, p=0.0004) and postoperative day 6 (136 mg/L vs. 52 mg/L, respectively - t-test, phttps://www.gastro-j.ru/jour/article/view/127низкая передняя резекцияколоректальный анастомознесостоятельностьпрокальцитонинс-реактивный белок |
| spellingShingle | Yu. A. Shelygin M. A. Tarasov M. A. Sukhina I. V. Zarodnyuk Ye. G. Rybakov Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage Российский журнал гастроэнтерологии, гепатологии, колопроктологии низкая передняя резекция колоректальный анастомоз несостоятельность прокальцитонин с-реактивный белок |
| title | Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage |
| title_full | Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage |
| title_fullStr | Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage |
| title_full_unstemmed | Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage |
| title_short | Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage |
| title_sort | procalcitonin and c reactive protein early predictors of low colorectal anastomotic leakage |
| topic | низкая передняя резекция колоректальный анастомоз несостоятельность прокальцитонин с-реактивный белок |
| url | https://www.gastro-j.ru/jour/article/view/127 |
| work_keys_str_mv | AT yuashelygin procalcitoninandcreactiveproteinearlypredictorsoflowcolorectalanastomoticleakage AT matarasov procalcitoninandcreactiveproteinearlypredictorsoflowcolorectalanastomoticleakage AT masukhina procalcitoninandcreactiveproteinearlypredictorsoflowcolorectalanastomoticleakage AT ivzarodnyuk procalcitoninandcreactiveproteinearlypredictorsoflowcolorectalanastomoticleakage AT yegrybakov procalcitoninandcreactiveproteinearlypredictorsoflowcolorectalanastomoticleakage |