LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis
In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of AS. In this study, we investigated the mechanism by which l...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2025.2487317 |
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| author | Xiaoliang Yin Xiaodong Chen Tao Wang Jianling Yang Jiahui Yu Jun Yang |
| author_facet | Xiaoliang Yin Xiaodong Chen Tao Wang Jianling Yang Jiahui Yu Jun Yang |
| author_sort | Xiaoliang Yin |
| collection | DOAJ |
| description | In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of AS. In this study, we investigated the mechanism by which lncRNA SCARNA8 affects macrophage cell burial to regulate AS. The cytosolic burial-associated target gene regulated by lncRNA SCARNA8 was PPARG. LncRNA SCARNA8 was increased in the carotid unstable plaque group, whereas PPARG was decreased. Ox-LDL led to the up-regulation of lncRNA SCARNA8 expression and apoptosis in Raw264.7 cells in a time-, concentration-dependent manner. Knockdown of lncRNA SCARNA8 upregulated PPARG and reduced apoptosis in Raw264.7 cells. In addition, knockdown of lncRNA SCARNA8 improved the stability of atherosclerotic plaques by promoting cellular burial of Raw264.7 cells. LncRNA SCARNA8 is a key regulator of plaque vulnerability, and targeting lncRNA SCARNA8 May provide a novel means for the prevention and treatment of AS. |
| format | Article |
| id | doaj-art-5c268adbd8e548dfba868280ef0553a0 |
| institution | OA Journals |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-5c268adbd8e548dfba868280ef0553a02025-08-20T01:51:25ZengTaylor & Francis GroupEpigenetics1559-22941559-23082025-12-0120110.1080/15592294.2025.2487317LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosisXiaoliang Yin0Xiaodong Chen1Tao Wang2Jianling Yang3Jiahui Yu4Jun Yang5Department of Neurosurgery, Peking University Third Hospital, Beijing, ChinaDepartment of Neurosurgery, Peking University Third Hospital, Beijing, ChinaDepartment of Neurosurgery, Peking University Third Hospital, Beijing, ChinaDepartment of Neurosurgery, Peking University Third Hospital, Beijing, ChinaDepartment of Neurosurgery, Peking University Third Hospital, Beijing, ChinaDepartment of Neurosurgery, Peking University Third Hospital, Beijing, ChinaIn recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of AS. In this study, we investigated the mechanism by which lncRNA SCARNA8 affects macrophage cell burial to regulate AS. The cytosolic burial-associated target gene regulated by lncRNA SCARNA8 was PPARG. LncRNA SCARNA8 was increased in the carotid unstable plaque group, whereas PPARG was decreased. Ox-LDL led to the up-regulation of lncRNA SCARNA8 expression and apoptosis in Raw264.7 cells in a time-, concentration-dependent manner. Knockdown of lncRNA SCARNA8 upregulated PPARG and reduced apoptosis in Raw264.7 cells. In addition, knockdown of lncRNA SCARNA8 improved the stability of atherosclerotic plaques by promoting cellular burial of Raw264.7 cells. LncRNA SCARNA8 is a key regulator of plaque vulnerability, and targeting lncRNA SCARNA8 May provide a novel means for the prevention and treatment of AS.https://www.tandfonline.com/doi/10.1080/15592294.2025.2487317Long noncoding RNAsatherosclerosismacrophage efferocytosisPPARG |
| spellingShingle | Xiaoliang Yin Xiaodong Chen Tao Wang Jianling Yang Jiahui Yu Jun Yang LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis Epigenetics Long noncoding RNAs atherosclerosis macrophage efferocytosis PPARG |
| title | LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis |
| title_full | LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis |
| title_fullStr | LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis |
| title_full_unstemmed | LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis |
| title_short | LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis |
| title_sort | lncrna scarna8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis |
| topic | Long noncoding RNAs atherosclerosis macrophage efferocytosis PPARG |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2025.2487317 |
| work_keys_str_mv | AT xiaoliangyin lncrnascarna8promotesatheroscleroticplaqueinstabilitybyinhibitingmacrophageefferocytosis AT xiaodongchen lncrnascarna8promotesatheroscleroticplaqueinstabilitybyinhibitingmacrophageefferocytosis AT taowang lncrnascarna8promotesatheroscleroticplaqueinstabilitybyinhibitingmacrophageefferocytosis AT jianlingyang lncrnascarna8promotesatheroscleroticplaqueinstabilitybyinhibitingmacrophageefferocytosis AT jiahuiyu lncrnascarna8promotesatheroscleroticplaqueinstabilitybyinhibitingmacrophageefferocytosis AT junyang lncrnascarna8promotesatheroscleroticplaqueinstabilitybyinhibitingmacrophageefferocytosis |