Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding
ABSTRACT Introduction Enfortumab vedotin (EV) has been reported to cause skin toxicity in some patients. We report a rare case of toxic epidermal necrolysis (TEN) induced by EV and complicated by severe gastrointestinal (GI) bleeding. Case Presentation A 70‐year‐old man with recurrent urothelial car...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
|
| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.70036 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850109230189641728 |
|---|---|
| author | Aika Matsuyama Takashi Kato Rion Kawase Mikinori Kobayashi Ayako Momota Yukiko Tsunoda Asaomi Yamaguchi Hiroki Hirabayashi Shoji Suzuki Masashi Kato |
| author_facet | Aika Matsuyama Takashi Kato Rion Kawase Mikinori Kobayashi Ayako Momota Yukiko Tsunoda Asaomi Yamaguchi Hiroki Hirabayashi Shoji Suzuki Masashi Kato |
| author_sort | Aika Matsuyama |
| collection | DOAJ |
| description | ABSTRACT Introduction Enfortumab vedotin (EV) has been reported to cause skin toxicity in some patients. We report a rare case of toxic epidermal necrolysis (TEN) induced by EV and complicated by severe gastrointestinal (GI) bleeding. Case Presentation A 70‐year‐old man with recurrent urothelial carcinoma developed a trunk rash at 16 days after EV administration. He presented to the emergency department with loss of consciousness and was diagnosed with TEN and septic shock. Although pulse steroid therapy improved his skin lesions, his abdominal symptoms progressively worsened. On Day 27, he developed massive GI bleeding. Despite intensive interventions, he died of multiple organ failure on Day 30. Conclusion This case highlights that Stevens–Johnson syndrome/TEN induced by EV can develop shortly after treatment, with delayed and potentially fatal GI manifestations. Given the challenges in managing established TEN, close monitoring for adverse events is essential. |
| format | Article |
| id | doaj-art-5c25dd51abff4b498a48e841a3e4d785 |
| institution | OA Journals |
| issn | 2577-171X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj-art-5c25dd51abff4b498a48e841a3e4d7852025-08-20T02:38:09ZengWileyIJU Case Reports2577-171X2025-07-018434835110.1002/iju5.70036Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal BleedingAika Matsuyama0Takashi Kato1Rion Kawase2Mikinori Kobayashi3Ayako Momota4Yukiko Tsunoda5Asaomi Yamaguchi6Hiroki Hirabayashi7Shoji Suzuki8Masashi Kato9Department of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Female Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Female Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanDepartment of Urology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya JapanABSTRACT Introduction Enfortumab vedotin (EV) has been reported to cause skin toxicity in some patients. We report a rare case of toxic epidermal necrolysis (TEN) induced by EV and complicated by severe gastrointestinal (GI) bleeding. Case Presentation A 70‐year‐old man with recurrent urothelial carcinoma developed a trunk rash at 16 days after EV administration. He presented to the emergency department with loss of consciousness and was diagnosed with TEN and septic shock. Although pulse steroid therapy improved his skin lesions, his abdominal symptoms progressively worsened. On Day 27, he developed massive GI bleeding. Despite intensive interventions, he died of multiple organ failure on Day 30. Conclusion This case highlights that Stevens–Johnson syndrome/TEN induced by EV can develop shortly after treatment, with delayed and potentially fatal GI manifestations. Given the challenges in managing established TEN, close monitoring for adverse events is essential.https://doi.org/10.1002/iju5.70036enfortumab vedotingastrointestinal bleedingtoxic epidermal necrolysisurothelial carcinoma |
| spellingShingle | Aika Matsuyama Takashi Kato Rion Kawase Mikinori Kobayashi Ayako Momota Yukiko Tsunoda Asaomi Yamaguchi Hiroki Hirabayashi Shoji Suzuki Masashi Kato Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding IJU Case Reports enfortumab vedotin gastrointestinal bleeding toxic epidermal necrolysis urothelial carcinoma |
| title | Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding |
| title_full | Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding |
| title_fullStr | Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding |
| title_full_unstemmed | Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding |
| title_short | Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding |
| title_sort | enfortumab vedotin induced toxic epidermal necrolysis in metastatic urothelial carcinoma complicated by severe gastrointestinal bleeding |
| topic | enfortumab vedotin gastrointestinal bleeding toxic epidermal necrolysis urothelial carcinoma |
| url | https://doi.org/10.1002/iju5.70036 |
| work_keys_str_mv | AT aikamatsuyama enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT takashikato enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT rionkawase enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT mikinorikobayashi enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT ayakomomota enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT yukikotsunoda enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT asaomiyamaguchi enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT hirokihirabayashi enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT shojisuzuki enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding AT masashikato enfortumabvedotininducedtoxicepidermalnecrolysisinmetastaticurothelialcarcinomacomplicatedbyseveregastrointestinalbleeding |