Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices
Objective. To determine whether initial biopsy performed by community or academic urologists affected rates of Gleason upgrading at a tertiary referral center. Gleason upgrading from biopsy to radical prostatectomy (RP) is an important event as treatment decisions are made based on the biopsy score....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2013/471234 |
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| _version_ | 1832552709223350272 |
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| author | Franklin Lee Henry Gottsch William J. Ellis Lawrence D. True Daniel W. Lin Jonathan L. Wright |
| author_facet | Franklin Lee Henry Gottsch William J. Ellis Lawrence D. True Daniel W. Lin Jonathan L. Wright |
| author_sort | Franklin Lee |
| collection | DOAJ |
| description | Objective. To determine whether initial biopsy performed by community or academic urologists affected rates of Gleason upgrading at a tertiary referral center. Gleason upgrading from biopsy to radical prostatectomy (RP) is an important event as treatment decisions are made based on the biopsy score. Materials and Methods. We identified men undergoing RP for Gleason 3+3 or 3+4 disease at a tertiary care academic center. Biopsy performed in the community was centrally reviewed at the academic center. Multivariate logistic regression was used to determine factors associated with Gleason upgrading. Results. We reviewed 1,348 men. There was no difference in upgrading whether the biopsy was performed at academic or community sites (OR 0.9, 95% CI 0.7–1.2). Increased risk of upgrading was seen in those with >1 positive core, older men, and those with higher PSAs. Secondary pattern 4 and larger prostate size were associated with a reduction in risk of upgrading. Compared to the smallest quartile of prostate size (<35 g), those in the highest quartile (>56 g) had a 49% reduction in risk of upgrading (OR 0.51, 95% CI 0.3–0.7). Conclusion. There was no difference in upgrading between where the biopsy was performed and community and academic urologists. |
| format | Article |
| id | doaj-art-5c25dd1b11b949bc85f1efd5f58aae4a |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-5c25dd1b11b949bc85f1efd5f58aae4a2025-02-03T05:58:07ZengWileyAdvances in Urology1687-63691687-63772013-01-01201310.1155/2013/471234471234Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic PracticesFranklin Lee0Henry Gottsch1William J. Ellis2Lawrence D. True3Daniel W. Lin4Jonathan L. Wright5Department of Urology, University of Washington School of Medicine, Health Sciences Building, 1959 NE Pacific, BB-1115, P.O. Box 356510, Seattle, WA 98195, USADepartment of Urology, University of Washington School of Medicine, Health Sciences Building, 1959 NE Pacific, BB-1115, P.O. Box 356510, Seattle, WA 98195, USADepartment of Urology, University of Washington School of Medicine, Health Sciences Building, 1959 NE Pacific, BB-1115, P.O. Box 356510, Seattle, WA 98195, USADepartment of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USADepartment of Urology, University of Washington School of Medicine, Health Sciences Building, 1959 NE Pacific, BB-1115, P.O. Box 356510, Seattle, WA 98195, USADepartment of Urology, University of Washington School of Medicine, Health Sciences Building, 1959 NE Pacific, BB-1115, P.O. Box 356510, Seattle, WA 98195, USAObjective. To determine whether initial biopsy performed by community or academic urologists affected rates of Gleason upgrading at a tertiary referral center. Gleason upgrading from biopsy to radical prostatectomy (RP) is an important event as treatment decisions are made based on the biopsy score. Materials and Methods. We identified men undergoing RP for Gleason 3+3 or 3+4 disease at a tertiary care academic center. Biopsy performed in the community was centrally reviewed at the academic center. Multivariate logistic regression was used to determine factors associated with Gleason upgrading. Results. We reviewed 1,348 men. There was no difference in upgrading whether the biopsy was performed at academic or community sites (OR 0.9, 95% CI 0.7–1.2). Increased risk of upgrading was seen in those with >1 positive core, older men, and those with higher PSAs. Secondary pattern 4 and larger prostate size were associated with a reduction in risk of upgrading. Compared to the smallest quartile of prostate size (<35 g), those in the highest quartile (>56 g) had a 49% reduction in risk of upgrading (OR 0.51, 95% CI 0.3–0.7). Conclusion. There was no difference in upgrading between where the biopsy was performed and community and academic urologists.http://dx.doi.org/10.1155/2013/471234 |
| spellingShingle | Franklin Lee Henry Gottsch William J. Ellis Lawrence D. True Daniel W. Lin Jonathan L. Wright Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices Advances in Urology |
| title | Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices |
| title_full | Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices |
| title_fullStr | Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices |
| title_full_unstemmed | Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices |
| title_short | Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices |
| title_sort | differences in upgrading of prostate cancer in prostatectomies between community and academic practices |
| url | http://dx.doi.org/10.1155/2013/471234 |
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