Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease
Parkinson’s disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory dysfunction, and pain. Despite their significant...
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2025-04-01
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| author | Kételin Vitória Matias Valeria de Cassia Gonçalves Fulvio Alexandre Scorza Josef Finsterer Rozana Mesquita Ciconelli Carla Alessandra Scorza |
| author_facet | Kételin Vitória Matias Valeria de Cassia Gonçalves Fulvio Alexandre Scorza Josef Finsterer Rozana Mesquita Ciconelli Carla Alessandra Scorza |
| author_sort | Kételin Vitória Matias |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory dysfunction, and pain. Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis is a natural bee-derived product, rich in bioactive compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, which holds potential in PD due to its multitarget and multipathway actions, addressing various underlying mechanisms of non-motor symptom diseases. Preclinical and clinical studies suggest that propolis may influence key pathological mechanisms in PD’s non-motor symptoms. Evidence points to its potential benefits in improving cognition, mood disorders, gastrointestinal health, and alleviating cardiovascular and sleep-related issues. Although research on propolis in non-motor symptoms of PD remains scarce, findings from related conditions suggest its ability to influence mechanisms associated with these symptoms. This review underscores the underexplored therapeutic potential of propolis in non-motor symptoms of PD, drawing on existing evidence and advocating for further research to fully assess its role in addressing these symptoms and improving patient outcomes. |
| format | Article |
| id | doaj-art-5c23e4b66a5f4cd39f4835c0a890df83 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-5c23e4b66a5f4cd39f4835c0a890df832025-08-20T02:28:15ZengMDPI AGMolecules1420-30492025-04-01308167210.3390/molecules30081672Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s DiseaseKételin Vitória Matias0Valeria de Cassia Gonçalves1Fulvio Alexandre Scorza2Josef Finsterer3Rozana Mesquita Ciconelli4Carla Alessandra Scorza5Disciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, BrazilNeurology and Neurophysiology Center, 1180 Vienna, AustriaDepartamento de Pesquisa da BP, A Beneficência Portuguesa de São Paulo, São Paulo 01323-001, SP, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, BrazilParkinson’s disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory dysfunction, and pain. Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis is a natural bee-derived product, rich in bioactive compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, which holds potential in PD due to its multitarget and multipathway actions, addressing various underlying mechanisms of non-motor symptom diseases. Preclinical and clinical studies suggest that propolis may influence key pathological mechanisms in PD’s non-motor symptoms. Evidence points to its potential benefits in improving cognition, mood disorders, gastrointestinal health, and alleviating cardiovascular and sleep-related issues. Although research on propolis in non-motor symptoms of PD remains scarce, findings from related conditions suggest its ability to influence mechanisms associated with these symptoms. This review underscores the underexplored therapeutic potential of propolis in non-motor symptoms of PD, drawing on existing evidence and advocating for further research to fully assess its role in addressing these symptoms and improving patient outcomes.https://www.mdpi.com/1420-3049/30/8/1672Parkinson’s diseasenon-motor symptomspropolisnatural compoundsneurodegeneration |
| spellingShingle | Kételin Vitória Matias Valeria de Cassia Gonçalves Fulvio Alexandre Scorza Josef Finsterer Rozana Mesquita Ciconelli Carla Alessandra Scorza Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease Molecules Parkinson’s disease non-motor symptoms propolis natural compounds neurodegeneration |
| title | Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease |
| title_full | Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease |
| title_fullStr | Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease |
| title_full_unstemmed | Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease |
| title_short | Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease |
| title_sort | nature s remedies exploring the potential of propolis to alleviate non motor manifestations of parkinson s disease |
| topic | Parkinson’s disease non-motor symptoms propolis natural compounds neurodegeneration |
| url | https://www.mdpi.com/1420-3049/30/8/1672 |
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