Risk of progression and the cause of mortality at chronic viral mixed-hepatitis
Aim of investigation. To estimate risk of development of liver function decompensation, hepatocellular carcinoma (HCC) development and prognostic factors of liver-related mortality in patients with chronic viral mixed-hepatitis.Material and methods. 82 patients with hepatitis D, 56 – with hepatitis...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2013-07-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1204 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860195631038464 |
|---|---|
| author | K. I. Yesmembetov D. T. Abdurakhmanov A. V. Odintsov N. A. Mukhin |
| author_facet | K. I. Yesmembetov D. T. Abdurakhmanov A. V. Odintsov N. A. Mukhin |
| author_sort | K. I. Yesmembetov |
| collection | DOAJ |
| description | Aim of investigation. To estimate risk of development of liver function decompensation, hepatocellular carcinoma (HCC) development and prognostic factors of liver-related mortality in patients with chronic viral mixed-hepatitis.Material and methods. 82 patients with hepatitis D, 56 – with hepatitis B+C and 20 – with hepatitis B+C+D, followed-up from Jan 2002 to Dec 2011, were included in the study. Results. During follow-up, decompensation occurred in 45.1, 8.9 and 62.5% of patients with compensated liver cirrhosis in groups D, BC and BCD, respectively. The 5-year risk of decompensation was 62%, 27% and 60%. HCC developed in 5.7% of patients, high AFP being the only predictor of HCC. The 5-year risk of HCC was 3.8%, 3.5% and 0%, respectively. 17.1%, 1.8% and 20% of patients died in groups D, BC and BCD, respectively, 5-year survival rate was 90%, 97% and 82%.Conclusions. In patients with chronic viral mixed hepatitis it is decompensation with liver failure development that determines prognosis and is principal cause of liver-related mortality in the most cases, not HCC development. |
| format | Article |
| id | doaj-art-5c236220d33544cfada1496914c77448 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2013-07-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-5c236220d33544cfada1496914c774482025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732013-07-012334955788Risk of progression and the cause of mortality at chronic viral mixed-hepatitisK. I. Yesmembetov0D. T. Abdurakhmanov1A. V. Odintsov2N. A. Mukhin3State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationAim of investigation. To estimate risk of development of liver function decompensation, hepatocellular carcinoma (HCC) development and prognostic factors of liver-related mortality in patients with chronic viral mixed-hepatitis.Material and methods. 82 patients with hepatitis D, 56 – with hepatitis B+C and 20 – with hepatitis B+C+D, followed-up from Jan 2002 to Dec 2011, were included in the study. Results. During follow-up, decompensation occurred in 45.1, 8.9 and 62.5% of patients with compensated liver cirrhosis in groups D, BC and BCD, respectively. The 5-year risk of decompensation was 62%, 27% and 60%. HCC developed in 5.7% of patients, high AFP being the only predictor of HCC. The 5-year risk of HCC was 3.8%, 3.5% and 0%, respectively. 17.1%, 1.8% and 20% of patients died in groups D, BC and BCD, respectively, 5-year survival rate was 90%, 97% and 82%.Conclusions. In patients with chronic viral mixed hepatitis it is decompensation with liver failure development that determines prognosis and is principal cause of liver-related mortality in the most cases, not HCC development.https://www.gastro-j.ru/jour/article/view/1204mixed-hepatitiscombined hepatitisliver cirrhosishepatocellular carcinomadecompensationhepatitis bhepatitis chepatitis delta |
| spellingShingle | K. I. Yesmembetov D. T. Abdurakhmanov A. V. Odintsov N. A. Mukhin Risk of progression and the cause of mortality at chronic viral mixed-hepatitis Российский журнал гастроэнтерологии, гепатологии, колопроктологии mixed-hepatitis combined hepatitis liver cirrhosis hepatocellular carcinoma decompensation hepatitis b hepatitis c hepatitis delta |
| title | Risk of progression and the cause of mortality at chronic viral mixed-hepatitis |
| title_full | Risk of progression and the cause of mortality at chronic viral mixed-hepatitis |
| title_fullStr | Risk of progression and the cause of mortality at chronic viral mixed-hepatitis |
| title_full_unstemmed | Risk of progression and the cause of mortality at chronic viral mixed-hepatitis |
| title_short | Risk of progression and the cause of mortality at chronic viral mixed-hepatitis |
| title_sort | risk of progression and the cause of mortality at chronic viral mixed hepatitis |
| topic | mixed-hepatitis combined hepatitis liver cirrhosis hepatocellular carcinoma decompensation hepatitis b hepatitis c hepatitis delta |
| url | https://www.gastro-j.ru/jour/article/view/1204 |
| work_keys_str_mv | AT kiyesmembetov riskofprogressionandthecauseofmortalityatchronicviralmixedhepatitis AT dtabdurakhmanov riskofprogressionandthecauseofmortalityatchronicviralmixedhepatitis AT avodintsov riskofprogressionandthecauseofmortalityatchronicviralmixedhepatitis AT namukhin riskofprogressionandthecauseofmortalityatchronicviralmixedhepatitis |