Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery
Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPARγ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CA...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1924907 |
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| author | Izabela Wojtkowska Tomasz A. Bonda Jadwiga Wolszakiewicz Jerzy Osak Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Maria M. Winnicka Ryszard Piotrowicz Janina Stępińska |
| author_facet | Izabela Wojtkowska Tomasz A. Bonda Jadwiga Wolszakiewicz Jerzy Osak Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Maria M. Winnicka Ryszard Piotrowicz Janina Stępińska |
| author_sort | Izabela Wojtkowska |
| collection | DOAJ |
| description | Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPARγ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was 397±85 m versus 420±93 m in non-HF. PPARγ mRNA expression was similar in both HF and non-HF groups. 6MWT distance 1 month after CABG was inversely correlated with PPARγ level only in HF group. Higher PPARγ expression was related to smaller LVEF change between 1 month and 1 year (R=0.18, p<0.05), especially in patients with HF. Higher initial levels of IL-6 in HF patients were correlated with longer distance in 6MWT one month after surgery and lower PPARγ expression. PPARγ expression is not related to LVEF before CABG and higher PPARγ expression in the myocardium of patients who are developing HF following CABG may have some protecting effect. |
| format | Article |
| id | doaj-art-5c1c90cc491042c0b6d02fdb55f9ad87 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-5c1c90cc491042c0b6d02fdb55f9ad872025-02-03T01:23:24ZengWileyPPAR Research1687-47571687-47652017-01-01201710.1155/2017/19249071924907Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass SurgeryIzabela Wojtkowska0Tomasz A. Bonda1Jadwiga Wolszakiewicz2Jerzy Osak3Andrzej Tysarowski4Katarzyna Seliga5Janusz A. Siedlecki6Maria M. Winnicka7Ryszard Piotrowicz8Janina Stępińska9Institute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St. 42, 04-628 Warsaw, PolandDepartment of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza St. 2c, 15-222 Bialystok, PolandInstitute of Cardiology, Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Alpejska St. 42, 04-628 Warsaw, PolandInstitute of Cardiology, Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Alpejska St. 42, 04-628 Warsaw, PolandInstitute of Oncology, Department of Molecular and Translational Oncology, Wawelska St. 15B, 02-034 Warsaw, PolandInstitute of Oncology, Department of Molecular and Translational Oncology, Wawelska St. 15B, 02-034 Warsaw, PolandInstitute of Oncology, Department of Molecular and Translational Oncology, Wawelska St. 15B, 02-034 Warsaw, PolandDepartment of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza St. 2c, 15-222 Bialystok, PolandInstitute of Cardiology, Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Alpejska St. 42, 04-628 Warsaw, PolandInstitute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St. 42, 04-628 Warsaw, PolandActivation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPARγ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was 397±85 m versus 420±93 m in non-HF. PPARγ mRNA expression was similar in both HF and non-HF groups. 6MWT distance 1 month after CABG was inversely correlated with PPARγ level only in HF group. Higher PPARγ expression was related to smaller LVEF change between 1 month and 1 year (R=0.18, p<0.05), especially in patients with HF. Higher initial levels of IL-6 in HF patients were correlated with longer distance in 6MWT one month after surgery and lower PPARγ expression. PPARγ expression is not related to LVEF before CABG and higher PPARγ expression in the myocardium of patients who are developing HF following CABG may have some protecting effect.http://dx.doi.org/10.1155/2017/1924907 |
| spellingShingle | Izabela Wojtkowska Tomasz A. Bonda Jadwiga Wolszakiewicz Jerzy Osak Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Maria M. Winnicka Ryszard Piotrowicz Janina Stępińska Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery PPAR Research |
| title | Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery |
| title_full | Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery |
| title_fullStr | Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery |
| title_full_unstemmed | Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery |
| title_short | Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery |
| title_sort | myocardial expression of pparγ and exercise capacity in patients after coronary artery bypass surgery |
| url | http://dx.doi.org/10.1155/2017/1924907 |
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