TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis
Introduction: Skeletal tuberculosis (TB) accounts for about 10 to 35% of extrapulmonary cases and the knee is the most frequent site after the spine and hip. The diagnosis is difficult and largely clinical. Case presentation: This is a case of a young Pakistani man with a history of joint pain fo...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2023-12-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/12618 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850148154951860224 |
|---|---|
| author | Serena Vita Claudia Mascia Blerta Kertusha Raffaella Marocco Ilaria Sauzullo Fabio Mengoni Irene Pozzetto Alessandro Scalzi Parni Nijhawan Stefano Savinelli Laura Fondaco Anna Carraro Cosmo Del Borgo Claudio Maria Mastroianni Miriam Lichtner |
| author_facet | Serena Vita Claudia Mascia Blerta Kertusha Raffaella Marocco Ilaria Sauzullo Fabio Mengoni Irene Pozzetto Alessandro Scalzi Parni Nijhawan Stefano Savinelli Laura Fondaco Anna Carraro Cosmo Del Borgo Claudio Maria Mastroianni Miriam Lichtner |
| author_sort | Serena Vita |
| collection | DOAJ |
| description |
Introduction: Skeletal tuberculosis (TB) accounts for about 10 to 35% of extrapulmonary cases and the knee is the most frequent site after the spine and hip. The diagnosis is difficult and largely clinical.
Case presentation: This is a case of a young Pakistani man with a history of joint pain for about 4 years, who was diagnosed with chronic arthritis of the right knee. Microscopy of synovial fluid and conventional diagnostic tests to identify Mycobacterium tuberculosis were negative, while a non-classical method based on intracellular cytokine flow cytometry response of CD4 T-cells in synovial fluid helped us to address the diagnosis, which was subsequently confirmed by Polymerase Chain Reaction (PCR).
Conclusions: Thanks to an innovative immunological approach, supported by PCR for detection of M. tuberculosis DNA, we were able to diagnose tuberculous arthritis of the knee, which allowed prompt initiation of treatment to reduce morbidity and mortality.
|
| format | Article |
| id | doaj-art-5c102ef3bb0c47aa9d38365c2055b422 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-5c102ef3bb0c47aa9d38365c2055b4222025-08-20T02:27:19ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-12-01171210.3855/jidc.12618TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritisSerena Vita0Claudia Mascia1Blerta Kertusha2Raffaella Marocco3Ilaria Sauzullo4Fabio Mengoni5Irene Pozzetto6Alessandro Scalzi7Parni Nijhawan8Stefano Savinelli9Laura Fondaco10Anna Carraro11Cosmo Del Borgo12Claudio Maria Mastroianni13Miriam Lichtner14Infectious Disease Unit, Santa Maria Goretti Hospital, Latina, ItalySapienza University of Rome, Rome, ItalySapienza University of Rome, Rome, ItalyInfectious Disease Unit, Santa Maria Goretti Hospital, Latina, ItalySapienza University of Rome, Rome, ItalyInfectious Disease Unit, Santa Maria Goretti Hospital, Latina, ItalyInfectious Disease Unit, Santa Maria Goretti Hospital, Latina, ItalyOrthopedics and Traumatology, Santa Maria Goretti Hospital, Latina, ItalySapienza University of Rome, Rome, ItalyCentre for Experimental Pathogen Host Research, University College Dublin, Dublin, IrelandSapienza University of Rome, Rome, ItalySapienza University of Rome, Rome, ItalyInfectious Disease Unit, Santa Maria Goretti Hospital, Latina, ItalySapienza University of Rome, Rome, ItalyInfectious Disease Unit, Santa Maria Goretti Hospital, Latina, Italy Introduction: Skeletal tuberculosis (TB) accounts for about 10 to 35% of extrapulmonary cases and the knee is the most frequent site after the spine and hip. The diagnosis is difficult and largely clinical. Case presentation: This is a case of a young Pakistani man with a history of joint pain for about 4 years, who was diagnosed with chronic arthritis of the right knee. Microscopy of synovial fluid and conventional diagnostic tests to identify Mycobacterium tuberculosis were negative, while a non-classical method based on intracellular cytokine flow cytometry response of CD4 T-cells in synovial fluid helped us to address the diagnosis, which was subsequently confirmed by Polymerase Chain Reaction (PCR). Conclusions: Thanks to an innovative immunological approach, supported by PCR for detection of M. tuberculosis DNA, we were able to diagnose tuberculous arthritis of the knee, which allowed prompt initiation of treatment to reduce morbidity and mortality. https://jidc.org/index.php/journal/article/view/12618Tuberculous arthritisTB diagnosisintracellular cytokines |
| spellingShingle | Serena Vita Claudia Mascia Blerta Kertusha Raffaella Marocco Ilaria Sauzullo Fabio Mengoni Irene Pozzetto Alessandro Scalzi Parni Nijhawan Stefano Savinelli Laura Fondaco Anna Carraro Cosmo Del Borgo Claudio Maria Mastroianni Miriam Lichtner TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis Journal of Infection in Developing Countries Tuberculous arthritis TB diagnosis intracellular cytokines |
| title | TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis |
| title_full | TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis |
| title_fullStr | TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis |
| title_full_unstemmed | TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis |
| title_short | TB specific intracellular cytokines production in Synovial liquid for diagnosis of tuberculous arthritis |
| title_sort | tb specific intracellular cytokines production in synovial liquid for diagnosis of tuberculous arthritis |
| topic | Tuberculous arthritis TB diagnosis intracellular cytokines |
| url | https://jidc.org/index.php/journal/article/view/12618 |
| work_keys_str_mv | AT serenavita tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT claudiamascia tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT blertakertusha tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT raffaellamarocco tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT ilariasauzullo tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT fabiomengoni tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT irenepozzetto tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT alessandroscalzi tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT parninijhawan tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT stefanosavinelli tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT laurafondaco tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT annacarraro tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT cosmodelborgo tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT claudiomariamastroianni tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis AT miriamlichtner tbspecificintracellularcytokinesproductioninsynovialliquidfordiagnosisoftuberculousarthritis |