Putrescine Depletion in <i>Leishmania donovani</i> Parasites Causes Immediate Proliferation Arrest Followed by an Apoptosis-like Cell Death

Putrescine Depletion in <i>Leishmania donovani</i> Parasites Causes Immediate Proliferation Arrest Followed by an Apoptosis-like Cell Death

The polyamine pathway in <i>Leishmania</i> parasites has emerged as a promising target for therapeutic intervention, yet the functions of polyamines in parasites remain largely unexplored. Ornithine decarboxylase (ODC) and spermidine synthase (SPDSYN) catalyze the sequential conversion o...

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Bibliographic Details
Main Authors: Julia Johnston, Jonathan Taylor, Surbhi Nahata, Angelica Gatica-Gomez, Yvette L. Anderson, Sophia Kiger, Thong Pham, Kayhan Karimi, Jasmin-Faith Lacar, Nicola S. Carter, Sigrid C. Roberts
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pathogens
Subjects:
<i>Leishmania</i>
polyamines
apoptosis
replication
mitochondria
starvation
Online Access:https://www.mdpi.com/2076-0817/14/2/137
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