Specific features of Brodie’s tumors
Brodie’s tumors are comparatively rare in oncological care and difficult-to-diagnose masses with an unpredictable course, predilection for recurrences, and a high probability of malignization. These tumors have a two-component structure with the predominant develop- ment of a connective tissue compo...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-08-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/245 |
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| author | D. A. Denchik I. K. Vorotnikov L. N. Lyubchenko O. A. Anurova A. V. Bykova |
| author_facet | D. A. Denchik I. K. Vorotnikov L. N. Lyubchenko O. A. Anurova A. V. Bykova |
| author_sort | D. A. Denchik |
| collection | DOAJ |
| description | Brodie’s tumors are comparatively rare in oncological care and difficult-to-diagnose masses with an unpredictable course, predilection for recurrences, and a high probability of malignization. These tumors have a two-component structure with the predominant develop- ment of a connective tissue component that is absolute in sarcomas and, in a group of fibroepithelial tumors, combines with the parallel development of epithelial tissue.The etiology of Brodie’s tumor is unclear, so is its pathogenesis. Molecular genetic studies have shown that the carriers of germ line missence-mutation R1699W in the BRCA1 gene have an increased risk of developing malignant Brodie’s tumor, but allele losses at the D22S264 locus of the TP5 gene determine the progression of the disease. Deletion of the short-arm of chromosome 1 (1p) and allelic imbalance are associated with the more aggressive course and recurrences of Brodie’s tumor.A complex clinicomorphological and molecular genetic study will help answer some questions concerning the diagnosis and treatment of Brodie’s tumors. |
| format | Article |
| id | doaj-art-5c0b22f659ad4bbaba881501db077af4 |
| institution | DOAJ |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-5c0b22f659ad4bbaba881501db077af42025-08-20T03:02:01ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-08-0103212310.17650/1994-4098-2010-0-3-21-23261Specific features of Brodie’s tumorsD. A. Denchik0I. K. Vorotnikov1L. N. Lyubchenko2O. A. Anurova3A. V. Bykova4Research Institute of Clinical Oncology, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowResearch Institute of Clinical Oncology, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowResearch Institute of Clinical Oncology, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowResearch Institute of Clinical Oncology, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowResearch Institute of Clinical Oncology, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowBrodie’s tumors are comparatively rare in oncological care and difficult-to-diagnose masses with an unpredictable course, predilection for recurrences, and a high probability of malignization. These tumors have a two-component structure with the predominant develop- ment of a connective tissue component that is absolute in sarcomas and, in a group of fibroepithelial tumors, combines with the parallel development of epithelial tissue.The etiology of Brodie’s tumor is unclear, so is its pathogenesis. Molecular genetic studies have shown that the carriers of germ line missence-mutation R1699W in the BRCA1 gene have an increased risk of developing malignant Brodie’s tumor, but allele losses at the D22S264 locus of the TP5 gene determine the progression of the disease. Deletion of the short-arm of chromosome 1 (1p) and allelic imbalance are associated with the more aggressive course and recurrences of Brodie’s tumor.A complex clinicomorphological and molecular genetic study will help answer some questions concerning the diagnosis and treatment of Brodie’s tumors.https://ojrs.abvpress.ru/ojrs/article/view/245brodie’s tumorsrecurrencemalignizationmolecular genetic markersbrca1/2tp53 genes |
| spellingShingle | D. A. Denchik I. K. Vorotnikov L. N. Lyubchenko O. A. Anurova A. V. Bykova Specific features of Brodie’s tumors Опухоли женской репродуктивной системы brodie’s tumors recurrence malignization molecular genetic markers brca1/2 tp53 genes |
| title | Specific features of Brodie’s tumors |
| title_full | Specific features of Brodie’s tumors |
| title_fullStr | Specific features of Brodie’s tumors |
| title_full_unstemmed | Specific features of Brodie’s tumors |
| title_short | Specific features of Brodie’s tumors |
| title_sort | specific features of brodie s tumors |
| topic | brodie’s tumors recurrence malignization molecular genetic markers brca1/2 tp53 genes |
| url | https://ojrs.abvpress.ru/ojrs/article/view/245 |
| work_keys_str_mv | AT dadenchik specificfeaturesofbrodiestumors AT ikvorotnikov specificfeaturesofbrodiestumors AT lnlyubchenko specificfeaturesofbrodiestumors AT oaanurova specificfeaturesofbrodiestumors AT avbykova specificfeaturesofbrodiestumors |