Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness
Purpose: Vascular invasion is a well-known independent prognostic factor in colon cancer and tumor sidedness is also being considered a prognostic factor. The aim of this study was to compare the oncological impact of vascular invasion depending on the tumor location in stages I to III colon cancer....
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The Korean Society of Endo-Laparoscopic & Robotic Surgery
2022-06-01
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| Series: | Journal of Minimally Invasive Surgery |
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| Online Access: | http://www.e-jmis.org/journal/view.html?doi=10.7602/jmis.2022.25.2.53 |
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| author | Moamen Shalkamy Abdelgawaad Shalkamy Jung Hoon Bae Chul Seung Lee Seung Rim Han Ji Hoon Kim Bong-Hyeon Kye In Kyu Lee Yoon Suk Lee |
| author_facet | Moamen Shalkamy Abdelgawaad Shalkamy Jung Hoon Bae Chul Seung Lee Seung Rim Han Ji Hoon Kim Bong-Hyeon Kye In Kyu Lee Yoon Suk Lee |
| author_sort | Moamen Shalkamy Abdelgawaad Shalkamy |
| collection | DOAJ |
| description | Purpose: Vascular invasion is a well-known independent prognostic factor in colon cancer and tumor sidedness is also being considered a prognostic factor. The aim of this study was to compare the oncological impact of vascular invasion depending on the tumor location in stages I to III colon cancer. Methods : A retrospective analysis was performed using data from patients who underwent curative resection between 2004 and 2015. Patients were divided into right-sided colon cancer (RCC) and left-sided colon cancer (LCC) groups according to the tumor location. Disease-free survival (DFS) and overall survival (OS) were compared between the RCC and LCC groups, depending on the presence of vascular invasion. Results : A total of 793 patients were included, of which 304 (38.3%) had RCC and 489 (61.7%) had LCC. DFS and OS did not differ significantly between the RCC and LCC groups. Vascular invasion was a poor prognostic factor for DFS in both RCC (hazard ratio [HR], 2.291; 95% confidence interval [CI], 1.186–4.425; p = 0.010) and LCC (HR, 1.848; 95% CI, 1.139–2.998; p = 0.011). Additionally, it was associated with significantly worse OS in the RCC (HR, 3.503; 95% CI, 1.681–7.300; p < 0.001), but not in the LCC group (HR, 1.676; 95% CI, 0.885–3.175; p = 0.109). Multivariate analysis revealed that vascular invasion was independently poor prognostic factor for OS in the RCC (HR, 3.186; 95% CI, 1.391–7.300; p = 0.006). Conclusion : This study demonstrated that RCC with vascular invasion had worse OS than LCC with vascular invasion. |
| format | Article |
| id | doaj-art-5c0a1c03ac144cd99cb035d5b5f7f0c9 |
| institution | DOAJ |
| issn | 2234-778X |
| language | English |
| publishDate | 2022-06-01 |
| publisher | The Korean Society of Endo-Laparoscopic & Robotic Surgery |
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| series | Journal of Minimally Invasive Surgery |
| spelling | doaj-art-5c0a1c03ac144cd99cb035d5b5f7f0c92025-08-20T02:43:15ZengThe Korean Society of Endo-Laparoscopic & Robotic SurgeryJournal of Minimally Invasive Surgery2234-778X2022-06-01252536210.7602/jmis.2022.25.2.53jmis.2022.25.2.53Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidednessMoamen Shalkamy Abdelgawaad Shalkamy0Jung Hoon Bae1Chul Seung Lee2Seung Rim Han3Ji Hoon Kim4Bong-Hyeon Kye5In Kyu Lee6Yoon Suk Lee7Division of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Colorectal Surgery, Department of Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, KoreaDivision of Colorectal Surgery, Department of Surgery, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, KoreaDivision of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaPurpose: Vascular invasion is a well-known independent prognostic factor in colon cancer and tumor sidedness is also being considered a prognostic factor. The aim of this study was to compare the oncological impact of vascular invasion depending on the tumor location in stages I to III colon cancer. Methods : A retrospective analysis was performed using data from patients who underwent curative resection between 2004 and 2015. Patients were divided into right-sided colon cancer (RCC) and left-sided colon cancer (LCC) groups according to the tumor location. Disease-free survival (DFS) and overall survival (OS) were compared between the RCC and LCC groups, depending on the presence of vascular invasion. Results : A total of 793 patients were included, of which 304 (38.3%) had RCC and 489 (61.7%) had LCC. DFS and OS did not differ significantly between the RCC and LCC groups. Vascular invasion was a poor prognostic factor for DFS in both RCC (hazard ratio [HR], 2.291; 95% confidence interval [CI], 1.186–4.425; p = 0.010) and LCC (HR, 1.848; 95% CI, 1.139–2.998; p = 0.011). Additionally, it was associated with significantly worse OS in the RCC (HR, 3.503; 95% CI, 1.681–7.300; p < 0.001), but not in the LCC group (HR, 1.676; 95% CI, 0.885–3.175; p = 0.109). Multivariate analysis revealed that vascular invasion was independently poor prognostic factor for OS in the RCC (HR, 3.186; 95% CI, 1.391–7.300; p = 0.006). Conclusion : This study demonstrated that RCC with vascular invasion had worse OS than LCC with vascular invasion.http://www.e-jmis.org/journal/view.html?doi=10.7602/jmis.2022.25.2.53colonic neoplasmsvascular invasionsurvivaltumor sidedness |
| spellingShingle | Moamen Shalkamy Abdelgawaad Shalkamy Jung Hoon Bae Chul Seung Lee Seung Rim Han Ji Hoon Kim Bong-Hyeon Kye In Kyu Lee Yoon Suk Lee Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness Journal of Minimally Invasive Surgery colonic neoplasms vascular invasion survival tumor sidedness |
| title | Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness |
| title_full | Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness |
| title_fullStr | Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness |
| title_full_unstemmed | Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness |
| title_short | Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness |
| title_sort | oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness |
| topic | colonic neoplasms vascular invasion survival tumor sidedness |
| url | http://www.e-jmis.org/journal/view.html?doi=10.7602/jmis.2022.25.2.53 |
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