Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis
ObjectiveTo evaluate the efficacy and safety of Shuxuening injection (SXNI) in the treatment of patients with intracerebral hemorrhage (ICH).MethodsThis study included randomized controlled trials published before 1 June 2024 in eight databases. Patients with ICH were included, with the control grou...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1537679/full |
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| author | Wenting Song Yaoyuan Liu Yaoyuan Liu Chaofan Kang Yazi Zhang Xing Yan Xinyao Jin Yuetong Wang Fengwen Yang Wentai Pang |
| author_facet | Wenting Song Yaoyuan Liu Yaoyuan Liu Chaofan Kang Yazi Zhang Xing Yan Xinyao Jin Yuetong Wang Fengwen Yang Wentai Pang |
| author_sort | Wenting Song |
| collection | DOAJ |
| description | ObjectiveTo evaluate the efficacy and safety of Shuxuening injection (SXNI) in the treatment of patients with intracerebral hemorrhage (ICH).MethodsThis study included randomized controlled trials published before 1 June 2024 in eight databases. Patients with ICH were included, with the control group receiving conventional treatment (CT) and the treatment group receiving additional SXNI on this basis. The primary outcome was neurological impairment score. The secondary outcomes were overall efficacy, cerebral hematoma volume, cerebral edema volume, activities of daily living (ADL) score, erythrocyte sedimentation rate (ESR), hematocrit (HCT), hypersensitive C-reactive protein (hs-CRP), low cut whole blood viscosity, high cut whole blood viscosity and adverse events (AE). The methodological quality of the included studies was assessed using the revised Cochrane Risk of Bias tool (ROB 2.0). For binary variables, risk ratios (RR) were calculated, while for continuous variables, mean differences (MD) or standardized mean differences (SMD) were calculated, based on 95% confidence intervals (CI).ResultsA total of 29 trials involving 3,012 participants were included. Compared with the control group, the treatment group demonstrated better performance in reducing neurological impairment score [SMD = −0.99, 95% CI −1.24, −0.73], improving overall efficacy [RR = 1.22, 95% CI 1.14, 1.30] and ADL score [SMD = 2.01, 95%CI 1.55, 2.46], as well as decreasing the cerebral hematoma volume [MD = −6.98, 95% CI −8.76, −5.20] and cerebral edema volume [MD = −3.67, 95%CI -5.27, −2.06], with statistically significant differences observed. Meanwhile, the incidence of AE in the treatment group was lower than that in the control group, with a statistically significant difference [RR = 0.63, 95%CI 0.41, 0.96].ConclusionThis study indicates that the combined use of SXNI and CT may be beneficial for the treatment of patients with cerebral hemorrhage compared to the use of CT alone. However, due to the moderate to very low certainty of evidence, it is advisable to conduct highquality clinical trials to validate the findings of this study. |
| format | Article |
| id | doaj-art-5c06847ae766487a9f3b61c33db9982d |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-5c06847ae766487a9f3b61c33db9982d2025-08-20T03:07:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15376791537679Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysisWenting Song0Yaoyuan Liu1Yaoyuan Liu2Chaofan Kang3Yazi Zhang4Xing Yan5Xinyao Jin6Yuetong Wang7Fengwen Yang8Wentai Pang9Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaObjectiveTo evaluate the efficacy and safety of Shuxuening injection (SXNI) in the treatment of patients with intracerebral hemorrhage (ICH).MethodsThis study included randomized controlled trials published before 1 June 2024 in eight databases. Patients with ICH were included, with the control group receiving conventional treatment (CT) and the treatment group receiving additional SXNI on this basis. The primary outcome was neurological impairment score. The secondary outcomes were overall efficacy, cerebral hematoma volume, cerebral edema volume, activities of daily living (ADL) score, erythrocyte sedimentation rate (ESR), hematocrit (HCT), hypersensitive C-reactive protein (hs-CRP), low cut whole blood viscosity, high cut whole blood viscosity and adverse events (AE). The methodological quality of the included studies was assessed using the revised Cochrane Risk of Bias tool (ROB 2.0). For binary variables, risk ratios (RR) were calculated, while for continuous variables, mean differences (MD) or standardized mean differences (SMD) were calculated, based on 95% confidence intervals (CI).ResultsA total of 29 trials involving 3,012 participants were included. Compared with the control group, the treatment group demonstrated better performance in reducing neurological impairment score [SMD = −0.99, 95% CI −1.24, −0.73], improving overall efficacy [RR = 1.22, 95% CI 1.14, 1.30] and ADL score [SMD = 2.01, 95%CI 1.55, 2.46], as well as decreasing the cerebral hematoma volume [MD = −6.98, 95% CI −8.76, −5.20] and cerebral edema volume [MD = −3.67, 95%CI -5.27, −2.06], with statistically significant differences observed. Meanwhile, the incidence of AE in the treatment group was lower than that in the control group, with a statistically significant difference [RR = 0.63, 95%CI 0.41, 0.96].ConclusionThis study indicates that the combined use of SXNI and CT may be beneficial for the treatment of patients with cerebral hemorrhage compared to the use of CT alone. However, due to the moderate to very low certainty of evidence, it is advisable to conduct highquality clinical trials to validate the findings of this study.https://www.frontiersin.org/articles/10.3389/fphar.2025.1537679/fullShuxuening injectioncerebral hemorrhageintracerebral hemorrhagesystematic reviewmeta-analysisrandomized controlled trials |
| spellingShingle | Wenting Song Yaoyuan Liu Yaoyuan Liu Chaofan Kang Yazi Zhang Xing Yan Xinyao Jin Yuetong Wang Fengwen Yang Wentai Pang Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis Frontiers in Pharmacology Shuxuening injection cerebral hemorrhage intracerebral hemorrhage systematic review meta-analysis randomized controlled trials |
| title | Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis |
| title_full | Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis |
| title_short | Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis |
| title_sort | efficacy and safety of shuxuening injection in intracerebral hemorrhage a systematic review and meta analysis |
| topic | Shuxuening injection cerebral hemorrhage intracerebral hemorrhage systematic review meta-analysis randomized controlled trials |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1537679/full |
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