Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023)
BackgroundGlioma is the most aggressive primary malignant tumor of the central nervous system, characterized by high recurrence rates and resistance to chemoradiotherapy, making therapeutic resistance a major challenge in neuro-oncology. Recent research emphasizes the role of the tumor microenvironm...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1539937/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206714139410432 |
|---|---|
| author | Shishi Yu Jinya Wu Yuan Jing Ping Lin Lang Lang Yifan Xiong Wangzhong Chen Wenhua Liu Changpeng Sun Yuntao Lu |
| author_facet | Shishi Yu Jinya Wu Yuan Jing Ping Lin Lang Lang Yifan Xiong Wangzhong Chen Wenhua Liu Changpeng Sun Yuntao Lu |
| author_sort | Shishi Yu |
| collection | DOAJ |
| description | BackgroundGlioma is the most aggressive primary malignant tumor of the central nervous system, characterized by high recurrence rates and resistance to chemoradiotherapy, making therapeutic resistance a major challenge in neuro-oncology. Recent research emphasizes the role of the tumor microenvironment (TME) and immune modulation in glioma progression and resistance. Despite these advances, a comprehensive bibliometric analysis of research trends in glioma chemoradiotherapy resistance over the past two decades is lacking. This study aims to systematically evaluate the research landscape, identify emerging hotspots, and provide guidance for future investigations.MethodsArticles on glioma chemoradiotherapy resistance published between 2003 and 2023 were retrieved from the Web of Science Core Collection, resulting in 4,528 publications. Bibliometric tools, including VOSviewer, CiteSpace, and R packages such as bibliometrix and ggplot2, were used to analyze co-authorship networks, keyword evolution, and citation bursts to identify collaboration patterns, thematic developments, and influential contributions.ResultsPublication output increased significantly between 2013 and 2022, peaking at 650 articles in 2022. Over 1,000 institutions from 88 countries contributed to this research. The United States, Switzerland, and Germany showed the highest citation impact, while China led in publication volume but demonstrated relatively lower citation influence. The research focus has shifted from traditional topics such as the “MGMT gene” to emerging areas including the “tumor microenvironment,” “immune infiltration,” and “nanoparticles.” The androgen receptor was identified as a promising but underexplored therapeutic target.ConclusionsResearch on glioma chemoradiotherapy resistance has seen substantial growth, with increasing emphasis on immune modulation, the tumor microenvironment, and novel therapeutic targets such as the androgen receptor. This study represents the first comprehensive bibliometric analysis of this field, providing a detailed overview of research trends and potential directions for future studies. The findings highlight the need for strengthened international collaboration and multidisciplinary approaches to address the challenges of therapeutic resistance in glioma. |
| format | Article |
| id | doaj-art-5c02c68b87db40e7922517a9606d8d38 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5c02c68b87db40e7922517a9606d8d382025-02-07T06:49:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15399371539937Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023)Shishi Yu0Jinya Wu1Yuan Jing2Ping Lin3Lang Lang4Yifan Xiong5Wangzhong Chen6Wenhua Liu7Changpeng Sun8Yuntao Lu9The Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaClinical Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaThe Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, ChinaNanfang hospital, Southern Medical University, Guangzhou, Guangdong, ChinaBackgroundGlioma is the most aggressive primary malignant tumor of the central nervous system, characterized by high recurrence rates and resistance to chemoradiotherapy, making therapeutic resistance a major challenge in neuro-oncology. Recent research emphasizes the role of the tumor microenvironment (TME) and immune modulation in glioma progression and resistance. Despite these advances, a comprehensive bibliometric analysis of research trends in glioma chemoradiotherapy resistance over the past two decades is lacking. This study aims to systematically evaluate the research landscape, identify emerging hotspots, and provide guidance for future investigations.MethodsArticles on glioma chemoradiotherapy resistance published between 2003 and 2023 were retrieved from the Web of Science Core Collection, resulting in 4,528 publications. Bibliometric tools, including VOSviewer, CiteSpace, and R packages such as bibliometrix and ggplot2, were used to analyze co-authorship networks, keyword evolution, and citation bursts to identify collaboration patterns, thematic developments, and influential contributions.ResultsPublication output increased significantly between 2013 and 2022, peaking at 650 articles in 2022. Over 1,000 institutions from 88 countries contributed to this research. The United States, Switzerland, and Germany showed the highest citation impact, while China led in publication volume but demonstrated relatively lower citation influence. The research focus has shifted from traditional topics such as the “MGMT gene” to emerging areas including the “tumor microenvironment,” “immune infiltration,” and “nanoparticles.” The androgen receptor was identified as a promising but underexplored therapeutic target.ConclusionsResearch on glioma chemoradiotherapy resistance has seen substantial growth, with increasing emphasis on immune modulation, the tumor microenvironment, and novel therapeutic targets such as the androgen receptor. This study represents the first comprehensive bibliometric analysis of this field, providing a detailed overview of research trends and potential directions for future studies. The findings highlight the need for strengthened international collaboration and multidisciplinary approaches to address the challenges of therapeutic resistance in glioma.https://www.frontiersin.org/articles/10.3389/fonc.2025.1539937/fullgliomachemoradiotherapy resistancetumor microenvironmentbibliometric analysisimmune infiltrationandrogen receptor |
| spellingShingle | Shishi Yu Jinya Wu Yuan Jing Ping Lin Lang Lang Yifan Xiong Wangzhong Chen Wenhua Liu Changpeng Sun Yuntao Lu Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) Frontiers in Oncology glioma chemoradiotherapy resistance tumor microenvironment bibliometric analysis immune infiltration androgen receptor |
| title | Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) |
| title_full | Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) |
| title_fullStr | Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) |
| title_full_unstemmed | Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) |
| title_short | Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) |
| title_sort | research trends in glioma chemoradiotherapy resistance a bibliometric analysis 2003 2023 |
| topic | glioma chemoradiotherapy resistance tumor microenvironment bibliometric analysis immune infiltration androgen receptor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1539937/full |
| work_keys_str_mv | AT shishiyu researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT jinyawu researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT yuanjing researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT pinglin researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT langlang researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT yifanxiong researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT wangzhongchen researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT wenhualiu researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT changpengsun researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 AT yuntaolu researchtrendsingliomachemoradiotherapyresistanceabibliometricanalysis20032023 |