The expression and significance of miR-378a in oral squamous cell carcinoma
[Objective] To investigate the expression of miR‐378a in oral squamous cell carcinoma (OSCC) tissues and its correlation with the prognosis of patients. [Methods] Subject recruitment consisted of 91 patients with OSCC, surgical procedures were carried out from March 2015 to March 2018. Real‐time qua...
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Editorial Office of Journal of Oral and Maxillofacial Surgery
2023-04-01
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| Series: | Kouqiang hemian waike zazhi |
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| Online Access: | https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2023.02.006 |
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| _version_ | 1849225099690901504 |
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| author | CHEN Yan JIANG Shengjun |
| author_facet | CHEN Yan JIANG Shengjun |
| author_sort | CHEN Yan |
| collection | DOAJ |
| description | [Objective] To investigate the expression of miR‐378a in oral squamous cell carcinoma (OSCC) tissues and its correlation with the prognosis of patients. [Methods] Subject recruitment consisted of 91 patients with OSCC, surgical procedures were carried out from March 2015 to March 2018. Real‐time quantitative polymerase chain reaction (RT‐qPCR) was used to detect the expressions of miR‐378a in OSCC and adjacent tissues. The patients were followed up on the first day after operation, and the deadline for follow‐up was March 31, 2021. With death or expiration of follow‐up as the end event, the death and overall survival time during the follow‐up period were recorded. [Results] The relative expression level of miR‐378a in OSCC tissues was lower than that in the adjacent tissues (P<0.001). The differences of the relative expression levels of miR‐378a in different TNM stage, degree of differentiation and lymph node metastasis were statistically significant (P<0.05). Kaplan‐Meier analysis showed that the average survival time of patients in the high expression group was 32.29 months, and the 3‐year survival rate was 73.81%, which was higher than 24.80 months and 30.61% in the low expression group (P<0.001). The expression of miR‐378a, TNM stage, degree of differentiation and lymph node metastasis were risk factors that affect the survival time of patients (P<0.05). [Conclusion] The present study revealed that the expression level of miR‐378a in the tissues of OSCC is weaker than that in the normal tissues. The expression intensity is related to TNM stage, degree of differentiation and lymph node metastasis. It is a risk factor that affects the prognosis of patients. |
| format | Article |
| id | doaj-art-5c01bc327e10420582721ec7bdcf2e4f |
| institution | Kabale University |
| issn | 1005-4979 |
| language | zho |
| publishDate | 2023-04-01 |
| publisher | Editorial Office of Journal of Oral and Maxillofacial Surgery |
| record_format | Article |
| series | Kouqiang hemian waike zazhi |
| spelling | doaj-art-5c01bc327e10420582721ec7bdcf2e4f2025-08-25T06:09:58ZzhoEditorial Office of Journal of Oral and Maxillofacial SurgeryKouqiang hemian waike zazhi1005-49792023-04-01332959810.3969/j.issn.1005-4979.2023.02.006The expression and significance of miR-378a in oral squamous cell carcinomaCHEN Yan0JIANG Shengjun1Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430000, Hubei Province, ChinaDepartment of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430000, Hubei Province, China[Objective] To investigate the expression of miR‐378a in oral squamous cell carcinoma (OSCC) tissues and its correlation with the prognosis of patients. [Methods] Subject recruitment consisted of 91 patients with OSCC, surgical procedures were carried out from March 2015 to March 2018. Real‐time quantitative polymerase chain reaction (RT‐qPCR) was used to detect the expressions of miR‐378a in OSCC and adjacent tissues. The patients were followed up on the first day after operation, and the deadline for follow‐up was March 31, 2021. With death or expiration of follow‐up as the end event, the death and overall survival time during the follow‐up period were recorded. [Results] The relative expression level of miR‐378a in OSCC tissues was lower than that in the adjacent tissues (P<0.001). The differences of the relative expression levels of miR‐378a in different TNM stage, degree of differentiation and lymph node metastasis were statistically significant (P<0.05). Kaplan‐Meier analysis showed that the average survival time of patients in the high expression group was 32.29 months, and the 3‐year survival rate was 73.81%, which was higher than 24.80 months and 30.61% in the low expression group (P<0.001). The expression of miR‐378a, TNM stage, degree of differentiation and lymph node metastasis were risk factors that affect the survival time of patients (P<0.05). [Conclusion] The present study revealed that the expression level of miR‐378a in the tissues of OSCC is weaker than that in the normal tissues. The expression intensity is related to TNM stage, degree of differentiation and lymph node metastasis. It is a risk factor that affects the prognosis of patients.https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2023.02.006oral squamous cell carcinomamir‐378aclinicopathological indicatorssurvival analysiscox proportional hazard regression model |
| spellingShingle | CHEN Yan JIANG Shengjun The expression and significance of miR-378a in oral squamous cell carcinoma Kouqiang hemian waike zazhi oral squamous cell carcinoma mir‐378a clinicopathological indicators survival analysis cox proportional hazard regression model |
| title | The expression and significance of miR-378a in oral squamous cell carcinoma |
| title_full | The expression and significance of miR-378a in oral squamous cell carcinoma |
| title_fullStr | The expression and significance of miR-378a in oral squamous cell carcinoma |
| title_full_unstemmed | The expression and significance of miR-378a in oral squamous cell carcinoma |
| title_short | The expression and significance of miR-378a in oral squamous cell carcinoma |
| title_sort | expression and significance of mir 378a in oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma mir‐378a clinicopathological indicators survival analysis cox proportional hazard regression model |
| url | https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2023.02.006 |
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