Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans
Abstract Background This study employs Caenorhabditis elegans (C. elegans) as a model organism to explore the anti-aging effects of hydroxytyrosol (HT) and its underlying mechanisms. Results The findings reveal that HT significantly extends the lifespan of C. elegans while improving their functional...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Biology Direct |
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| Online Access: | https://doi.org/10.1186/s13062-025-00634-x |
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| author | Nannan Du Lishuo Song Ruigang Yang Kexin Liu Zubiao Niu Zhanfeng Zhang Qiang Sun |
| author_facet | Nannan Du Lishuo Song Ruigang Yang Kexin Liu Zubiao Niu Zhanfeng Zhang Qiang Sun |
| author_sort | Nannan Du |
| collection | DOAJ |
| description | Abstract Background This study employs Caenorhabditis elegans (C. elegans) as a model organism to explore the anti-aging effects of hydroxytyrosol (HT) and its underlying mechanisms. Results The findings reveal that HT significantly extends the lifespan of C. elegans while improving their functional performance (motility and pharyngeal function), and antioxidant capacity when administered on the first day of adulthood (D1). However, its efficacy diminishes when treatment begins on or after the third day of adulthood (D3). HT prolongs lifespan through a mechanism akin to that of skn-1 modulating the oxidative stress pathway. Conclusions This study suggests that the administration timing is an important factor for of anti-oxidation compounds to be effective in counteracting aging. |
| format | Article |
| id | doaj-art-5bfec486abc442f3bf0b54d980cd5d4b |
| institution | OA Journals |
| issn | 1745-6150 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj-art-5bfec486abc442f3bf0b54d980cd5d4b2025-08-20T02:29:26ZengBMCBiology Direct1745-61502025-05-012011810.1186/s13062-025-00634-xEarly-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegansNannan Du0Lishuo Song1Ruigang Yang2Kexin Liu3Zubiao Niu4Zhanfeng Zhang5Qiang Sun6Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical ScienceLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical ScienceLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical ScienceSchool of Medicine, South China University of TechnologyLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical ScienceLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical ScienceLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical ScienceAbstract Background This study employs Caenorhabditis elegans (C. elegans) as a model organism to explore the anti-aging effects of hydroxytyrosol (HT) and its underlying mechanisms. Results The findings reveal that HT significantly extends the lifespan of C. elegans while improving their functional performance (motility and pharyngeal function), and antioxidant capacity when administered on the first day of adulthood (D1). However, its efficacy diminishes when treatment begins on or after the third day of adulthood (D3). HT prolongs lifespan through a mechanism akin to that of skn-1 modulating the oxidative stress pathway. Conclusions This study suggests that the administration timing is an important factor for of anti-oxidation compounds to be effective in counteracting aging.https://doi.org/10.1186/s13062-025-00634-xHydroxytyrosolCaenorhabditis elegansAnti-agingOxidative stress |
| spellingShingle | Nannan Du Lishuo Song Ruigang Yang Kexin Liu Zubiao Niu Zhanfeng Zhang Qiang Sun Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans Biology Direct Hydroxytyrosol Caenorhabditis elegans Anti-aging Oxidative stress |
| title | Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans |
| title_full | Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans |
| title_fullStr | Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans |
| title_full_unstemmed | Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans |
| title_short | Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans |
| title_sort | early stage administration of hydroxytyrosol extends lifespan and delays aging in c elegans |
| topic | Hydroxytyrosol Caenorhabditis elegans Anti-aging Oxidative stress |
| url | https://doi.org/10.1186/s13062-025-00634-x |
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