Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression

Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression

Abstract The WD‐repeat (WDR) family affects carcinogenesis, but its role in the immune microenvironment is poorly characterized. Although functional loss or gain of WDR6 does not markedly change in vitro proliferative and invasive capacity of HCC cells, its deficiency in hepa1‐6 cells drastically in...

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Bibliographic Details
Main Authors: Heng Zhang, Gang Chen, Xing Feng, Huiwen Song, Lingbing Meng, Yao Fu, Jun Yang, Zhiwen Fan, Youxiang Ding, Zhijie Du, Jianchao Wang, Li Yang, Jun Zhang, Lixia Sun, Zhigang Liu, Zhiyong Zhang, Quanhai Li, Xiangshan Fan
Format: Article
Language:English
Published: Springer Nature 2023-03-01
Series:EMBO Molecular Medicine
Subjects:
MDSC
PD‐1
TNFα
UVRAG
WDR6
Online Access:https://doi.org/10.15252/emmm.202215924
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