Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?
It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) used in positron emission tomograph...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2017-10-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.215485 |
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| author | Reyhan Köroglu İsmail Köksal Fikri Şimşek Fatma Gezer Ersoy Kekilli Bülent Ünal |
| author_facet | Reyhan Köroglu İsmail Köksal Fikri Şimşek Fatma Gezer Ersoy Kekilli Bülent Ünal |
| author_sort | Reyhan Köroglu |
| collection | DOAJ |
| description | It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT). After FDG injection, PET/CT screening was applied within the 1st h (PET-1) and in the 2nd h (PET-2). SUVmax, SUVmean, SUVmax RI, and SUVmean RI of every image were calculated qualitatively and semiquantitatively. The correlation between quantitative and semiquantitative PET parameters and biologic as well as clinicopathologic prognosis factors was evaluated. Statistically, significant positive correlation was found between lymph nodes (LNs), which were evaluated by clinical picture, clinical stage as well as histopathologically and quantitative PET parameters (SUVmax1, SUVmax2, , RImax, SUVmean1, SUVmean2, RImean) (P < 0.05). While statistically significant correlation with RImax was detected only by LN (histopathological), correlations with RImean were detected by clinical picture, clinical stage, metabolic stage, and LN (histopathological). Statistically, significant correlation was found between RImax and estrogen receptor in patients who were histopathologically diagnosed with invasive ductal carcinoma (n = 34) (P < 0.05). We detected correlations between biologic and clinicopathologic prognostic factors and SUVmax as well as SUVmean values in breast carcinoma. SUVmean values may provide important knowledge when the correlation between prognostic factors and PET parameters is investigated even if they are not used routinely. |
| format | Article |
| id | doaj-art-5bfc5376d64b4030b290756938779692 |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-5bfc5376d64b4030b2907569387796922025-08-20T01:57:32ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122017-10-01160427528010.4103/1450-1147.215485Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?Reyhan Köroglu0İsmail Köksal1Fikri Şimşek2Fatma Gezer3Ersoy Kekilli4Bülent Ünal5Department of Nuclear Medicine, Faculty of Medicine, Karabuk University, KarabukDepartment of Nuclear Medicine, Malatya State Hospital, MalatyaDepartment of Nuclear Medicine, Elazig Education and Research Hospital, ElazigDepartment of Anesthesiology and Reanimation, Education and Research Hospital, Yıldırım Beyazıt University, AnkaraDepartment of Nuclear Medicine, Faculty of Medicine, Inonu University, MalatyaDepartment of Oncologic Surgery, Faculty of Medicine, Inonu University, MalatyaIt was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT). After FDG injection, PET/CT screening was applied within the 1st h (PET-1) and in the 2nd h (PET-2). SUVmax, SUVmean, SUVmax RI, and SUVmean RI of every image were calculated qualitatively and semiquantitatively. The correlation between quantitative and semiquantitative PET parameters and biologic as well as clinicopathologic prognosis factors was evaluated. Statistically, significant positive correlation was found between lymph nodes (LNs), which were evaluated by clinical picture, clinical stage as well as histopathologically and quantitative PET parameters (SUVmax1, SUVmax2, , RImax, SUVmean1, SUVmean2, RImean) (P < 0.05). While statistically significant correlation with RImax was detected only by LN (histopathological), correlations with RImean were detected by clinical picture, clinical stage, metabolic stage, and LN (histopathological). Statistically, significant correlation was found between RImax and estrogen receptor in patients who were histopathologically diagnosed with invasive ductal carcinoma (n = 34) (P < 0.05). We detected correlations between biologic and clinicopathologic prognostic factors and SUVmax as well as SUVmean values in breast carcinoma. SUVmean values may provide important knowledge when the correlation between prognostic factors and PET parameters is investigated even if they are not used routinely.http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.215485breast cancerprognostic factorssemiquantitative positron emission tomography parameters |
| spellingShingle | Reyhan Köroglu İsmail Köksal Fikri Şimşek Fatma Gezer Ersoy Kekilli Bülent Ünal Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value? World Journal of Nuclear Medicine breast cancer prognostic factors semiquantitative positron emission tomography parameters |
| title | Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value? |
| title_full | Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value? |
| title_fullStr | Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value? |
| title_full_unstemmed | Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value? |
| title_short | Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value? |
| title_sort | considering the relationship between quantitative parameters and prognostic factors in breast cancer can mean standardized uptake value be an alternative to maximum standardized uptake value |
| topic | breast cancer prognostic factors semiquantitative positron emission tomography parameters |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.215485 |
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