Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.

Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.

Gamma-retroviruses and lentiviruses integrate non-randomly in mammalian genomes, with specific preferences for active chromatin, promoters and regulatory regions. Gene transfer vectors derived from gamma-retroviruses target at high frequency genes involved in the control of growth, development and d...

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Bibliographic Details
Main Authors: Barbara Felice, Claudia Cattoglio, Davide Cittaro, Anna Testa, Annarita Miccio, Giuliana Ferrari, Lucilla Luzi, Alessandra Recchia, Fulvio Mavilio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004571&type=printable
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