Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh
Objective To determine optimal waist circumference (WC) cut-off points for identifying metabolic syndrome (MetS) in Bangladeshi adults, with the aim of enhancing diagnostic accuracy specific to this population.Design Cross-sectional analysis.Setting Rural community in Chandra, Bangladesh.Participant...
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BMJ Publishing Group
2025-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/3/e093159.full |
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| author | A K Azad Khan Shamim Khan Hajera Mahtab Tasnima Siddiquee Bishwajit Bhowmik Sanjida Binte Munir Hafiza Nasrin Nayla Cristina Do Vale Moreira Sharif Mahmood Tanjimul Islam Fahmida Mahmud Iasmin Haque |
| author_facet | A K Azad Khan Shamim Khan Hajera Mahtab Tasnima Siddiquee Bishwajit Bhowmik Sanjida Binte Munir Hafiza Nasrin Nayla Cristina Do Vale Moreira Sharif Mahmood Tanjimul Islam Fahmida Mahmud Iasmin Haque |
| author_sort | A K Azad Khan |
| collection | DOAJ |
| description | Objective To determine optimal waist circumference (WC) cut-off points for identifying metabolic syndrome (MetS) in Bangladeshi adults, with the aim of enhancing diagnostic accuracy specific to this population.Design Cross-sectional analysis.Setting Rural community in Chandra, Bangladesh.Participants A total of 2293 adults aged 20 years and older.Primary and secondary outcome measures MetS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Receiver operating characteristic (ROC) curves and Youden’s Index were used to identify WC cut-off points that maximised sensitivity and specificity for diagnosing MetS. Restricted cubic spline regression was employed to explore the non-linear relationship between WC and MetS risk.Results The optimal WC cut-off points for predicting MetS were 90 cm for men (sensitivity 55.2%, specificity 94.3%, OR 12.5, 95% CI 8.6 to 18.0) and 80 cm for women (sensitivity 86.7%, specificity 71.9%, OR 15.6, 95% CI 11.4 to 21.3). The area under the ROC curve was 0.819 for men and 0.827 for women. Non-linear analysis indicated a significant increase in MetS risk beyond these thresholds, with a steeper risk gradient observed in men.Conclusions This study establishes WC cut-off points of 90 cm for men and 80 cm for women as optimal for diagnosing MetS in Bangladeshi adults, underscoring the necessity of population-specific diagnostic criteria to improve early detection and management. |
| format | Article |
| id | doaj-art-5bf9badd9fd541b7be2808fc8ddd40ca |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-5bf9badd9fd541b7be2808fc8ddd40ca2025-08-20T02:49:46ZengBMJ Publishing GroupBMJ Open2044-60552025-03-0115310.1136/bmjopen-2024-093159Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural BangladeshA K Azad Khan0Shamim Khan1Hajera Mahtab2Tasnima Siddiquee3Bishwajit Bhowmik4Sanjida Binte Munir5Hafiza Nasrin6Nayla Cristina Do Vale Moreira7Sharif Mahmood8Tanjimul Islam9Fahmida Mahmud10Iasmin Haque111 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh2 Nord Universitet, Bodo, Norway3 University of Central Arkansas, Conway, Arkansas, USA1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh1 Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, BangladeshObjective To determine optimal waist circumference (WC) cut-off points for identifying metabolic syndrome (MetS) in Bangladeshi adults, with the aim of enhancing diagnostic accuracy specific to this population.Design Cross-sectional analysis.Setting Rural community in Chandra, Bangladesh.Participants A total of 2293 adults aged 20 years and older.Primary and secondary outcome measures MetS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Receiver operating characteristic (ROC) curves and Youden’s Index were used to identify WC cut-off points that maximised sensitivity and specificity for diagnosing MetS. Restricted cubic spline regression was employed to explore the non-linear relationship between WC and MetS risk.Results The optimal WC cut-off points for predicting MetS were 90 cm for men (sensitivity 55.2%, specificity 94.3%, OR 12.5, 95% CI 8.6 to 18.0) and 80 cm for women (sensitivity 86.7%, specificity 71.9%, OR 15.6, 95% CI 11.4 to 21.3). The area under the ROC curve was 0.819 for men and 0.827 for women. Non-linear analysis indicated a significant increase in MetS risk beyond these thresholds, with a steeper risk gradient observed in men.Conclusions This study establishes WC cut-off points of 90 cm for men and 80 cm for women as optimal for diagnosing MetS in Bangladeshi adults, underscoring the necessity of population-specific diagnostic criteria to improve early detection and management.https://bmjopen.bmj.com/content/15/3/e093159.full |
| spellingShingle | A K Azad Khan Shamim Khan Hajera Mahtab Tasnima Siddiquee Bishwajit Bhowmik Sanjida Binte Munir Hafiza Nasrin Nayla Cristina Do Vale Moreira Sharif Mahmood Tanjimul Islam Fahmida Mahmud Iasmin Haque Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh BMJ Open |
| title | Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh |
| title_full | Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh |
| title_fullStr | Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh |
| title_full_unstemmed | Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh |
| title_short | Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh |
| title_sort | optimal cut off points for waist circumference in the definition of metabolic syndrome a cross sectional study in rural bangladesh |
| url | https://bmjopen.bmj.com/content/15/3/e093159.full |
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