Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction

Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction

Abstract Bile acid overload critically drives the pathogenesis of cholestatic liver injury (CLI). While ceramide metabolism has garnered increasing interest in liver research, the role of ceramides in CLI remains unclear. This study investigates the function of alkaline ceramidase 3 (ACER3)-catalyze...

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Main Authors: Leyi Liao, Ziying Liu, Lei Liu, Can Huang, Yiyi Li, Cungui Mao, Ruijuan Xu, Haiqing Liu, Cuiting Liu, Yonghong Peng, Tingying Lei, Hanbiao Liang, Sheng Yu, Jianping Qian, Xianqiu Wu, Biao Wang, Yixiong Lin, Jie Zhou, Qingping Li, Chuanjiang Li, Kai Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57330-7
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