The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes

The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes

Abstract The protein alpha-synuclein (αSyn) plays a pivotal role in the pathogenesis of synucleinopathies, including Parkinson’s disease and multiple system atrophy, with growing evidence indicating that lipid dyshomeostasis is a key phenotype in these neurodegenerative disorders. Previously, we ide...

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Main Authors: Peter A. Barbuti, Cristina Guardia-Laguarta, Taekyung Yun, Zena K. Chatila, Xena Flowers, Chantel Wong, Bruno F. R. Santos, Simone B. Larsen, James S. Lotti, Nobutaka Hattori, Elizabeth Bradshaw, Ulf Dettmer, Saranna Fanning, Vilas Menon, Hasini Reddy, Andrew F. Teich, Rejko Krüger, Estela Area-Gomez, Serge Przedborski
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00960-x
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