AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia
The role of hypoxia in benign meningiomas is less clear than that in the malignant meningiomas. Hypoxia-induced transcription factor 1 subunit alpha (HIF-1α) and its downstream signaling pathways play a central role in the mechanism of hypoxia. HIF-1α forms a complex with the aryl hydrocarbon recept...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2023/6840271 |
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| author | Maria L. Perepechaeva Lyubov S. Klyushova Alevtina Y. Grishanova |
| author_facet | Maria L. Perepechaeva Lyubov S. Klyushova Alevtina Y. Grishanova |
| author_sort | Maria L. Perepechaeva |
| collection | DOAJ |
| description | The role of hypoxia in benign meningiomas is less clear than that in the malignant meningiomas. Hypoxia-induced transcription factor 1 subunit alpha (HIF-1α) and its downstream signaling pathways play a central role in the mechanism of hypoxia. HIF-1α forms a complex with the aryl hydrocarbon receptor nuclear translocator (ARNT) protein and can compete for ARNT with aryl hydrocarbon receptor (AhR). In this work, the status of HIF-1α- and AhR-dependent signaling pathways was investigated in World Health Organization (WHO) grade 1 meningioma and patient-derived tumor primary cell culture under hypoxic conditions. mRNA levels of HIF-1α, AhR, and of their target genes as well as of ARNT and nuclear receptor coactivator NCOA2 were determined in tumor tissues from patients in whom the tumor was promptly removed either with or without prior endovascular embolization. Using the patient-derived nonembolized tumor primary cell culture, the effects of a hypoxia mimetic cobalt chloride (CoCl2) and an activator of the AhR signaling pathway benzo(α)pyrene (B[a]P) on mRNA levels of HIF-1α, AhR, and their target genes were investigated. Our findings show active functioning of AhR signaling in meningioma tissue of patients with tumor embolization and crosstalk between HIF-1α and AhR signaling in meningeal cells under hypoxia. |
| format | Article |
| id | doaj-art-5be6f25206f7402ea2ff3522f93a0cfb |
| institution | Kabale University |
| issn | 1687-8884 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-5be6f25206f7402ea2ff3522f93a0cfb2025-08-20T03:34:48ZengWileyInternational Journal of Cell Biology1687-88842023-01-01202310.1155/2023/6840271AhR and HIF-1α Signaling Pathways in Benign Meningioma under HypoxiaMaria L. Perepechaeva0Lyubov S. Klyushova1Alevtina Y. Grishanova2Institute of Molecular Biology and BiophysicsInstitute of Molecular Biology and BiophysicsInstitute of Molecular Biology and BiophysicsThe role of hypoxia in benign meningiomas is less clear than that in the malignant meningiomas. Hypoxia-induced transcription factor 1 subunit alpha (HIF-1α) and its downstream signaling pathways play a central role in the mechanism of hypoxia. HIF-1α forms a complex with the aryl hydrocarbon receptor nuclear translocator (ARNT) protein and can compete for ARNT with aryl hydrocarbon receptor (AhR). In this work, the status of HIF-1α- and AhR-dependent signaling pathways was investigated in World Health Organization (WHO) grade 1 meningioma and patient-derived tumor primary cell culture under hypoxic conditions. mRNA levels of HIF-1α, AhR, and of their target genes as well as of ARNT and nuclear receptor coactivator NCOA2 were determined in tumor tissues from patients in whom the tumor was promptly removed either with or without prior endovascular embolization. Using the patient-derived nonembolized tumor primary cell culture, the effects of a hypoxia mimetic cobalt chloride (CoCl2) and an activator of the AhR signaling pathway benzo(α)pyrene (B[a]P) on mRNA levels of HIF-1α, AhR, and their target genes were investigated. Our findings show active functioning of AhR signaling in meningioma tissue of patients with tumor embolization and crosstalk between HIF-1α and AhR signaling in meningeal cells under hypoxia.http://dx.doi.org/10.1155/2023/6840271 |
| spellingShingle | Maria L. Perepechaeva Lyubov S. Klyushova Alevtina Y. Grishanova AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia International Journal of Cell Biology |
| title | AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia |
| title_full | AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia |
| title_fullStr | AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia |
| title_full_unstemmed | AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia |
| title_short | AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia |
| title_sort | ahr and hif 1α signaling pathways in benign meningioma under hypoxia |
| url | http://dx.doi.org/10.1155/2023/6840271 |
| work_keys_str_mv | AT marialperepechaeva ahrandhif1asignalingpathwaysinbenignmeningiomaunderhypoxia AT lyubovsklyushova ahrandhif1asignalingpathwaysinbenignmeningiomaunderhypoxia AT alevtinaygrishanova ahrandhif1asignalingpathwaysinbenignmeningiomaunderhypoxia |