Potential of Curcumin and Its Analogs in Glioblastoma Therapy
Curcumin, a polyphenol found in turmeric, demonstrates multifaceted anti-cancer activity against glioblastoma. Its therapeutic potential stems from its ability to modulate various molecular pathways implicated in glioblastoma development and progression, enhance the effectiveness of radiation therap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/3/351 |
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| author | Agnieszka Nowacka Ewa Ziółkowska Wojciech Smuczyński Dominika Bożiłow Maciej Śniegocki |
| author_facet | Agnieszka Nowacka Ewa Ziółkowska Wojciech Smuczyński Dominika Bożiłow Maciej Śniegocki |
| author_sort | Agnieszka Nowacka |
| collection | DOAJ |
| description | Curcumin, a polyphenol found in turmeric, demonstrates multifaceted anti-cancer activity against glioblastoma. Its therapeutic potential stems from its ability to modulate various molecular pathways implicated in glioblastoma development and progression, enhance the effectiveness of radiation therapy, and induce cancer cell death through diverse mechanisms, including apoptosis, autophagy, and cell cycle arrest. These combined actions make curcumin a promising candidate for glioblastoma treatment, warranting further investigation into its clinical application. In this review, we summarize the latest research on curcumin and its analogs’ potential in glioblastoma therapy. |
| format | Article |
| id | doaj-art-5be57deaae714d149ab47b51535e4150 |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-5be57deaae714d149ab47b51535e41502025-08-20T02:42:45ZengMDPI AGAntioxidants2076-39212025-03-0114335110.3390/antiox14030351Potential of Curcumin and Its Analogs in Glioblastoma TherapyAgnieszka Nowacka0Ewa Ziółkowska1Wojciech Smuczyński2Dominika Bożiłow3Maciej Śniegocki4Department of Neurosurgery, Collegium Medicum in Bydgoszcz, Nicolas Copernicus University in Toruń, ul. Curie Skłodowskiej 9, 85-094 Bydgoszcz, PolandDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Physiotherapy, Collegium Medicum in Bydgoszcz, Nicolas Copernicus University in Toruń, ul. Techników 3, 85-801 Bydgoszcz, PolandAnaesthesiology and Intensive Care Clinical Ward, The 10th Military Research Hospital and Polyclinic, ul. Powstańców Warszawy 5, 85-681 Bydgoszcz, PolandDepartment of Neurosurgery, Collegium Medicum in Bydgoszcz, Nicolas Copernicus University in Toruń, ul. Curie Skłodowskiej 9, 85-094 Bydgoszcz, PolandCurcumin, a polyphenol found in turmeric, demonstrates multifaceted anti-cancer activity against glioblastoma. Its therapeutic potential stems from its ability to modulate various molecular pathways implicated in glioblastoma development and progression, enhance the effectiveness of radiation therapy, and induce cancer cell death through diverse mechanisms, including apoptosis, autophagy, and cell cycle arrest. These combined actions make curcumin a promising candidate for glioblastoma treatment, warranting further investigation into its clinical application. In this review, we summarize the latest research on curcumin and its analogs’ potential in glioblastoma therapy.https://www.mdpi.com/2076-3921/14/3/351curcuminglioblastomaGBManti-cancerglioblastoma therapyoxidative stress |
| spellingShingle | Agnieszka Nowacka Ewa Ziółkowska Wojciech Smuczyński Dominika Bożiłow Maciej Śniegocki Potential of Curcumin and Its Analogs in Glioblastoma Therapy Antioxidants curcumin glioblastoma GBM anti-cancer glioblastoma therapy oxidative stress |
| title | Potential of Curcumin and Its Analogs in Glioblastoma Therapy |
| title_full | Potential of Curcumin and Its Analogs in Glioblastoma Therapy |
| title_fullStr | Potential of Curcumin and Its Analogs in Glioblastoma Therapy |
| title_full_unstemmed | Potential of Curcumin and Its Analogs in Glioblastoma Therapy |
| title_short | Potential of Curcumin and Its Analogs in Glioblastoma Therapy |
| title_sort | potential of curcumin and its analogs in glioblastoma therapy |
| topic | curcumin glioblastoma GBM anti-cancer glioblastoma therapy oxidative stress |
| url | https://www.mdpi.com/2076-3921/14/3/351 |
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