cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products
Digestive diseases remain a major challenge to public health systems globally. Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon gene (STING) play important roles in innate immunity as well as inflammatory responses. Dysregulation of the cGAS-STING pathway has been demonstrated to be an im...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1594120/full |
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| author | Dan Long Chenhan Mao Ying Zhu Yin Xu |
| author_facet | Dan Long Chenhan Mao Ying Zhu Yin Xu |
| author_sort | Dan Long |
| collection | DOAJ |
| description | Digestive diseases remain a major challenge to public health systems globally. Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon gene (STING) play important roles in innate immunity as well as inflammatory responses. Dysregulation of the cGAS-STING pathway has been demonstrated to be an important pathogenetic mechanism in diverse gastrointestinal diseases. Therefore, targeting the cGAS-STING pathway is a potential therapeutic strategy for digestive diseases. Encouragingly, increasing studies have revealed that natural plant products are promising candidates for the treatment of digestive disorders. This review discussed the research progress of cGAS-STING pathway mediating common digestive diseases, including inflammatory bowel disease, liver disease, colorectal cancer, gastric cancer, esophageal cancer, pancreatitis, and pancreatic cancer. In addition, we systematically summarized recent advances in the treatment of gastrointestinal disorders with phytochemicals that target the cGAS-STING pathway. |
| format | Article |
| id | doaj-art-5be4e6de3da1414a8ba97b0f3a47ec02 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-5be4e6de3da1414a8ba97b0f3a47ec022025-08-20T03:21:44ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.15941201594120cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant productsDan Long0Chenhan Mao1Ying Zhu2Yin Xu3The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaThe First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaThe First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDigestive diseases remain a major challenge to public health systems globally. Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon gene (STING) play important roles in innate immunity as well as inflammatory responses. Dysregulation of the cGAS-STING pathway has been demonstrated to be an important pathogenetic mechanism in diverse gastrointestinal diseases. Therefore, targeting the cGAS-STING pathway is a potential therapeutic strategy for digestive diseases. Encouragingly, increasing studies have revealed that natural plant products are promising candidates for the treatment of digestive disorders. This review discussed the research progress of cGAS-STING pathway mediating common digestive diseases, including inflammatory bowel disease, liver disease, colorectal cancer, gastric cancer, esophageal cancer, pancreatitis, and pancreatic cancer. In addition, we systematically summarized recent advances in the treatment of gastrointestinal disorders with phytochemicals that target the cGAS-STING pathway.https://www.frontiersin.org/articles/10.3389/fnut.2025.1594120/fullcGASSTINGdigestive diseasestraditional Chinese medicineactive ingredients |
| spellingShingle | Dan Long Chenhan Mao Ying Zhu Yin Xu cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products Frontiers in Nutrition cGAS STING digestive diseases traditional Chinese medicine active ingredients |
| title | cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products |
| title_full | cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products |
| title_fullStr | cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products |
| title_full_unstemmed | cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products |
| title_short | cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products |
| title_sort | cgas sting pathway as a promising target for digestive diseases insights from natural plant products |
| topic | cGAS STING digestive diseases traditional Chinese medicine active ingredients |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1594120/full |
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