Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791965 |
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| _version_ | 1850225714926714880 |
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| author | K. Mealy A. Clooney P. Marks T. Hennessy J. Jackson |
| author_facet | K. Mealy A. Clooney P. Marks T. Hennessy J. Jackson |
| author_sort | K. Mealy |
| collection | DOAJ |
| description | The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to caecal ligation and puncture (CLP). Thirty-six h following surgery the animals were killed and blood taken for full blood count, total protein, albumin, α, β and γ globulin fractions on serum electrophoresis, complement C3 and transferrin levels. Danazol increased the α1, α2 and β1 globulin serum protein fractions in comparison with no surgery and CLP alone groups. These results indicate that danazol increases plasma acute phase proteins, as measured by electrophoresis, in this model of intra-abdominal sepsis. |
| format | Article |
| id | doaj-art-5be455f12799452ea742a6beea38e1ee |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5be455f12799452ea742a6beea38e1ee2025-08-20T02:05:16ZengWileyMediators of Inflammation0962-93511466-18611997-01-0161697210.1080/09629359791965Effects of anabolic steroids on acute phase responses in intra-abdominal sepsisK. Mealy0A. Clooney1P. Marks2T. Hennessy3J. Jackson4Department of Surgery, Trinity College and St James's Hospital, Dublin, IrelandDepartment of Immunology, St James's Hospital and Dublin Institute of Technology, Dublin, IrelandDepartment of Surgery, Trinity College and St James's Hospital, Dublin, IrelandDepartment of Surgery, Trinity College and St James's Hospital, Dublin, IrelandDepartment of Immunology, St James's Hospital and Dublin Institute of Technology, Dublin, IrelandThe acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to caecal ligation and puncture (CLP). Thirty-six h following surgery the animals were killed and blood taken for full blood count, total protein, albumin, α, β and γ globulin fractions on serum electrophoresis, complement C3 and transferrin levels. Danazol increased the α1, α2 and β1 globulin serum protein fractions in comparison with no surgery and CLP alone groups. These results indicate that danazol increases plasma acute phase proteins, as measured by electrophoresis, in this model of intra-abdominal sepsis.http://dx.doi.org/10.1080/09629359791965 |
| spellingShingle | K. Mealy A. Clooney P. Marks T. Hennessy J. Jackson Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis Mediators of Inflammation |
| title | Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis |
| title_full | Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis |
| title_fullStr | Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis |
| title_full_unstemmed | Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis |
| title_short | Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis |
| title_sort | effects of anabolic steroids on acute phase responses in intra abdominal sepsis |
| url | http://dx.doi.org/10.1080/09629359791965 |
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