Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI
ObjectivesTo qualitatively and quantitatively compare the image quality of readout-segmented echo planar imaging (rs-EPI) and single-shot echo planar imaging (ss-EPI) for diffusion-weighted (DWI) rectal MRI, as well as the heterogeneous predictive value of the apparent diffusion coefficient (ADC) va...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1457238/full |
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| author | Mingrui Song Yichuan Liang Huiying Wang Lei Shi Quanliang Mao Haonan Zhao Zhehao Zhang Aijing Li Yuning Pan |
| author_facet | Mingrui Song Yichuan Liang Huiying Wang Lei Shi Quanliang Mao Haonan Zhao Zhehao Zhang Aijing Li Yuning Pan |
| author_sort | Mingrui Song |
| collection | DOAJ |
| description | ObjectivesTo qualitatively and quantitatively compare the image quality of readout-segmented echo planar imaging (rs-EPI) and single-shot echo planar imaging (ss-EPI) for diffusion-weighted (DWI) rectal MRI, as well as the heterogeneous predictive value of the apparent diffusion coefficient (ADC) values obtained by the two DWI techniques.MethodsThe rs-EPI and ss-EPI images were subjectively assessed for lesion sharpness, display of normal structure, overall image quality, geometric distortion, and anatomical differences. The signal-to-noise ratio (SNR), contrast ratio (CR), contrast-to-noise ratio (CNR), and ADC values were objectively compared. Pearson’s correlations and ROC analysis were used to explore the relationships of ADC values obtained by the two techniques and nucleus related antigen (Ki-67) and hypoxia inducible factor-1α (HIF-1α).ResultsEighty patients with rectal cancer (RC) were included. Lesion sharpness, normal structure display, overall image quality, geometric distortion and anatomical structure differences in the rs-EPI DWI group were higher than in the ss-EPI DWI group (P<0.001). SNR, CNR and CR in the rs-EPI DWI group were higher than in the ss-EPI DWI group (P<0.001). ADC values were not different. ROC analysis showed that the area under the curve (AUC) of high Ki-67 and HIF-1α expression levels as predicted by the average ADC of ss-EPI and rs-EPI DWI were 0.82 (95%CI: 0.72-0.92), 0.77 (95%CI: 0.67-0.88), and 0.81 (95%CI: 0.72-0.91), 0.82 (95%CI: 0.72-0.91), respectively, with similar predictive values between the 2 techniques (P=0.23, 0.75).Conclusionrs-EPI DWI can improve image quality and the ADC value is associated with pathologic markers of tumor aggression. |
| format | Article |
| id | doaj-art-5be27fd41e4b475580b2cd89f25d14b8 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5be27fd41e4b475580b2cd89f25d14b82025-08-20T03:34:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.14572381457238Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRIMingrui Song0Yichuan Liang1Huiying Wang2Lei Shi3Quanliang Mao4Haonan Zhao5Zhehao Zhang6Aijing Li7Yuning Pan8Department of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaHealth Management Center, Shandong Chronic Disease Hospital, Qingdao, Shandong, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaObjectivesTo qualitatively and quantitatively compare the image quality of readout-segmented echo planar imaging (rs-EPI) and single-shot echo planar imaging (ss-EPI) for diffusion-weighted (DWI) rectal MRI, as well as the heterogeneous predictive value of the apparent diffusion coefficient (ADC) values obtained by the two DWI techniques.MethodsThe rs-EPI and ss-EPI images were subjectively assessed for lesion sharpness, display of normal structure, overall image quality, geometric distortion, and anatomical differences. The signal-to-noise ratio (SNR), contrast ratio (CR), contrast-to-noise ratio (CNR), and ADC values were objectively compared. Pearson’s correlations and ROC analysis were used to explore the relationships of ADC values obtained by the two techniques and nucleus related antigen (Ki-67) and hypoxia inducible factor-1α (HIF-1α).ResultsEighty patients with rectal cancer (RC) were included. Lesion sharpness, normal structure display, overall image quality, geometric distortion and anatomical structure differences in the rs-EPI DWI group were higher than in the ss-EPI DWI group (P<0.001). SNR, CNR and CR in the rs-EPI DWI group were higher than in the ss-EPI DWI group (P<0.001). ADC values were not different. ROC analysis showed that the area under the curve (AUC) of high Ki-67 and HIF-1α expression levels as predicted by the average ADC of ss-EPI and rs-EPI DWI were 0.82 (95%CI: 0.72-0.92), 0.77 (95%CI: 0.67-0.88), and 0.81 (95%CI: 0.72-0.91), 0.82 (95%CI: 0.72-0.91), respectively, with similar predictive values between the 2 techniques (P=0.23, 0.75).Conclusionrs-EPI DWI can improve image quality and the ADC value is associated with pathologic markers of tumor aggression.https://www.frontiersin.org/articles/10.3389/fonc.2025.1457238/fullimaging qualityreadout-segmented echo planar imagingsingle-shot echo planar imagingdiffusion-weighted imagingKi-67hypoxia inducible facor-1α |
| spellingShingle | Mingrui Song Yichuan Liang Huiying Wang Lei Shi Quanliang Mao Haonan Zhao Zhehao Zhang Aijing Li Yuning Pan Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI Frontiers in Oncology imaging quality readout-segmented echo planar imaging single-shot echo planar imaging diffusion-weighted imaging Ki-67 hypoxia inducible facor-1α |
| title | Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI |
| title_full | Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI |
| title_fullStr | Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI |
| title_full_unstemmed | Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI |
| title_short | Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI |
| title_sort | assessment of the imaging quality and heterogeneous predictive value of readout segmented echo planar imaging for diffusion weighted rectal mri |
| topic | imaging quality readout-segmented echo planar imaging single-shot echo planar imaging diffusion-weighted imaging Ki-67 hypoxia inducible facor-1α |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1457238/full |
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