The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
Purpose. Two-sample Mendelian randomization (MR) was conducted to assess the causal relationship between angina pectoris and gout. Material and Methods. Based on genome-wide association studies, single nucleotide polymorphisms (SNPs) that were closely associated with gout were selected from the UK B...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2024/4564596 |
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| author | Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang |
| author_facet | Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang |
| author_sort | Jian Xiong |
| collection | DOAJ |
| description | Purpose. Two-sample Mendelian randomization (MR) was conducted to assess the causal relationship between angina pectoris and gout. Material and Methods. Based on genome-wide association studies, single nucleotide polymorphisms (SNPs) that were closely associated with gout were selected from the UK Biobank–Neale Lab (ukb-a-107) as genetic instrumental variables. Considering that gout is characterized by elevated blood uric acid levels, SNPs related to blood uric acid levels were screened from BioBank Japan (bbj-a-57) as auxiliary gene instrumental variables. SNPs closely associated with angina pectoris onset were screened from the FINN dataset (finn-b-I9_ANGINA) as outcome variables. Two-sample MR was conducted, with inverse variance weighting (IVW) of the random effects model as the primary result, along with the weighted median method (WME) and the MR-Egger regression method. To further confirm the causal relationship between angina and gout incidence, a meta-analysis was conducted on the IVW results of the ukb-a-107 and bbj-a-57. Results. The odds ratios and 95% confidence intervals of the IVW, WME, and MR-Egger results of ukb-a-107 were (OR = 33.72; 95% CI: 2.07∼550.38), (OR = 57.94; 95% CI: 2.75∼1219.82), and (OR = 96.38; 95% CI: 0.6∼15556.93), respectively. The P values of IVW and WME were 0.014 and 0.014 (both <0.05), respectively, indicating that the development of angina pectoris was significantly associated with the incidence of gout. The odds ratios and 95% confidence intervals of the IVW, WME, and MR-Egger about bbj-a-57 were (OR = 1.20; 95% CI: 1.07∼1.34), (OR = 1.19; 95% CI: 1.02∼1.38), and (OR = 1.30; 95% CI; 1.06∼1.60), respectively. The P values of IVW, WME and MR-Egger were 0.001, 0.027 and 0.017 (all <0.05), respectively, indicating a significant correlation between angina and blood uric acid levels. Scatter plots of ukb-a-107 and bbj-a-57 showed that the causal association estimates of the IVW, MR-Egger, and weighted median methods were similar and that the MR results were accurate. Funnel plots and the MR-Egger intercept of ukb-a-107 and bbj-a-57 showed the absence of horizontal pleiotropy. The leave-out sensitivity analysis results of ukb-a-107 and bbj-a-57 are stable. The meta-analysis of IVW results for ukb-a-107 and bbj-a-57 showed (OR = 1.20; 95% CI: 1.07–1.34, P=0.02), confirming that gout characterized by high blood uric acid levels significantly increases the risk of angina attacks. Conclusions. This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris. |
| format | Article |
| id | doaj-art-5be1f8f5338b4d4a8a7210c9c231d2b5 |
| institution | Kabale University |
| issn | 1918-1523 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
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| series | Pain Research and Management |
| spelling | doaj-art-5be1f8f5338b4d4a8a7210c9c231d2b52025-08-20T03:34:48ZengWileyPain Research and Management1918-15232024-01-01202410.1155/2024/4564596The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian RandomizationJian Xiong0Yuxin Sun1Hui Huang2Yu Liu3Fayang Ling4Yin Wei5Qianhua Zheng6Wenchuan Qi7Fanrong Liang8Chengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineGuangxi University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicinePurpose. Two-sample Mendelian randomization (MR) was conducted to assess the causal relationship between angina pectoris and gout. Material and Methods. Based on genome-wide association studies, single nucleotide polymorphisms (SNPs) that were closely associated with gout were selected from the UK Biobank–Neale Lab (ukb-a-107) as genetic instrumental variables. Considering that gout is characterized by elevated blood uric acid levels, SNPs related to blood uric acid levels were screened from BioBank Japan (bbj-a-57) as auxiliary gene instrumental variables. SNPs closely associated with angina pectoris onset were screened from the FINN dataset (finn-b-I9_ANGINA) as outcome variables. Two-sample MR was conducted, with inverse variance weighting (IVW) of the random effects model as the primary result, along with the weighted median method (WME) and the MR-Egger regression method. To further confirm the causal relationship between angina and gout incidence, a meta-analysis was conducted on the IVW results of the ukb-a-107 and bbj-a-57. Results. The odds ratios and 95% confidence intervals of the IVW, WME, and MR-Egger results of ukb-a-107 were (OR = 33.72; 95% CI: 2.07∼550.38), (OR = 57.94; 95% CI: 2.75∼1219.82), and (OR = 96.38; 95% CI: 0.6∼15556.93), respectively. The P values of IVW and WME were 0.014 and 0.014 (both <0.05), respectively, indicating that the development of angina pectoris was significantly associated with the incidence of gout. The odds ratios and 95% confidence intervals of the IVW, WME, and MR-Egger about bbj-a-57 were (OR = 1.20; 95% CI: 1.07∼1.34), (OR = 1.19; 95% CI: 1.02∼1.38), and (OR = 1.30; 95% CI; 1.06∼1.60), respectively. The P values of IVW, WME and MR-Egger were 0.001, 0.027 and 0.017 (all <0.05), respectively, indicating a significant correlation between angina and blood uric acid levels. Scatter plots of ukb-a-107 and bbj-a-57 showed that the causal association estimates of the IVW, MR-Egger, and weighted median methods were similar and that the MR results were accurate. Funnel plots and the MR-Egger intercept of ukb-a-107 and bbj-a-57 showed the absence of horizontal pleiotropy. The leave-out sensitivity analysis results of ukb-a-107 and bbj-a-57 are stable. The meta-analysis of IVW results for ukb-a-107 and bbj-a-57 showed (OR = 1.20; 95% CI: 1.07–1.34, P=0.02), confirming that gout characterized by high blood uric acid levels significantly increases the risk of angina attacks. Conclusions. This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.http://dx.doi.org/10.1155/2024/4564596 |
| spellingShingle | Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization Pain Research and Management |
| title | The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization |
| title_full | The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization |
| title_fullStr | The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization |
| title_full_unstemmed | The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization |
| title_short | The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization |
| title_sort | causal relationship between angina pectoris and gout based on two sample mendelian randomization |
| url | http://dx.doi.org/10.1155/2024/4564596 |
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