A review of gut microbiota as a therapeutic approach for Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder that affects the brain–gut axis, manifesting through both motor dysfunction and nonmotor symptoms. While several factors contribute to PD, the precise cause remains unknown. Research studies suggest that an altered gut microbiota (GM) plays a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | MGM Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.4103/mgmj.mgmj_296_24 |
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| author | Debosree Ghosh Suvendu Ghosh Madhurima Sharma Sutapa Datta |
| author_facet | Debosree Ghosh Suvendu Ghosh Madhurima Sharma Sutapa Datta |
| author_sort | Debosree Ghosh |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a neurodegenerative disorder that affects the brain–gut axis, manifesting through both motor dysfunction and nonmotor symptoms. While several factors contribute to PD, the precise cause remains unknown. Research studies suggest that an altered gut microbiota (GM) plays a key role in PD pathophysiology. Gut dysbiosis compromises the integrity of the intestinal epithelium, increasing gastrointestinal permeability. This, in turn, activates the innate immune system, leading to systemic inflammation, whereas the adaptive immune system responds to bacterial proteins through cross-reactivity with human antigens. The altered GM promotes the accumulation of alpha-synuclein fibrils in the intestinal neural plexus, which are then transported to the central nervous system, driving the core pathological process of PD. This review focuses on the connection between gut dysbiosis, PD pathology, and current microbial-based therapeutic interventions. Furthermore, research into innovative approaches to modulate the GM and reinforce gut epithelial integrity is crucial to halting or slowing PD progression. |
| format | Article |
| id | doaj-art-5bd87cef92f74360af41541534c54646 |
| institution | Kabale University |
| issn | 2347-7946 2347-7962 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj-art-5bd87cef92f74360af41541534c546462025-01-17T10:55:34ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622024-12-0111476377110.4103/mgmj.mgmj_296_24A review of gut microbiota as a therapeutic approach for Parkinson’s diseaseDebosree GhoshSuvendu GhoshMadhurima SharmaSutapa DattaParkinson’s disease (PD) is a neurodegenerative disorder that affects the brain–gut axis, manifesting through both motor dysfunction and nonmotor symptoms. While several factors contribute to PD, the precise cause remains unknown. Research studies suggest that an altered gut microbiota (GM) plays a key role in PD pathophysiology. Gut dysbiosis compromises the integrity of the intestinal epithelium, increasing gastrointestinal permeability. This, in turn, activates the innate immune system, leading to systemic inflammation, whereas the adaptive immune system responds to bacterial proteins through cross-reactivity with human antigens. The altered GM promotes the accumulation of alpha-synuclein fibrils in the intestinal neural plexus, which are then transported to the central nervous system, driving the core pathological process of PD. This review focuses on the connection between gut dysbiosis, PD pathology, and current microbial-based therapeutic interventions. Furthermore, research into innovative approaches to modulate the GM and reinforce gut epithelial integrity is crucial to halting or slowing PD progression.https://doi.org/10.4103/mgmj.mgmj_296_24alpha-synucleinbrain–gut–microbiota axisgut microbiotaparkinson’s disease |
| spellingShingle | Debosree Ghosh Suvendu Ghosh Madhurima Sharma Sutapa Datta A review of gut microbiota as a therapeutic approach for Parkinson’s disease MGM Journal of Medical Sciences alpha-synuclein brain–gut–microbiota axis gut microbiota parkinson’s disease |
| title | A review of gut microbiota as a therapeutic approach for Parkinson’s disease |
| title_full | A review of gut microbiota as a therapeutic approach for Parkinson’s disease |
| title_fullStr | A review of gut microbiota as a therapeutic approach for Parkinson’s disease |
| title_full_unstemmed | A review of gut microbiota as a therapeutic approach for Parkinson’s disease |
| title_short | A review of gut microbiota as a therapeutic approach for Parkinson’s disease |
| title_sort | review of gut microbiota as a therapeutic approach for parkinson s disease |
| topic | alpha-synuclein brain–gut–microbiota axis gut microbiota parkinson’s disease |
| url | https://doi.org/10.4103/mgmj.mgmj_296_24 |
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