Swimming exercise reduces H-type vessels by down-regulating the Hif-1α/VEGFa pathway in mice with osteoarthritis of the knee

Swimming exercise reduces H-type vessels by down-regulating the Hif-1α/VEGFa pathway in mice with osteoarthritis of the knee

Abstract Aims The efficacy of swimming in managing knee osteoarthritis (KOA) is well documented. However, the potential of swimming to regulate the Hif-1α/VEGFa pathway and thereby hindering the formation of subchondral bone H-type vessels, remains to be fully elucidated. Methods A mouse model of KO...

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Bibliographic Details
Main Authors: Lingxiao Huang, Wanchun Du, Xing Jin, Bo Chen, Zhaoxiang Meng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Knee osteoarthritis
Swimming
H-type vessels
Hif-1α
VEGFa
Online Access:https://doi.org/10.1186/s12891-025-08903-6
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