Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease
Background. We examine whether cystatin C, a surrogate marker of renal function, could identify patients with chronic kidney disease (CKD) with an increased risk of renal disease progression, death, or cardiovascular events. Methods. Data were obtained for 180 patients, with a diagnosis of chronic r...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/127943 |
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| author | Ana Vigil Emilia Condés Luis Vigil Paloma Gallar Aniana Oliet Olimpia Ortega Isabel Rodriguez Milagros Ortiz Juan Carlos Herrero Carmen Mon Gabriela Cobo Juana Jimenez |
| author_facet | Ana Vigil Emilia Condés Luis Vigil Paloma Gallar Aniana Oliet Olimpia Ortega Isabel Rodriguez Milagros Ortiz Juan Carlos Herrero Carmen Mon Gabriela Cobo Juana Jimenez |
| author_sort | Ana Vigil |
| collection | DOAJ |
| description | Background. We examine whether cystatin C, a surrogate marker of renal function, could identify patients with chronic kidney disease (CKD) with an increased risk of renal disease progression, death, or cardiovascular events. Methods. Data were obtained for 180 patients, with a diagnosis of chronic renal failure based on serum creatinine estimated glomerular filtration rate (eGFRcreat) <90 mL/min/1.73 m2. This population was grouped in tertiles according to cystatin C and creatinine values at baseline. Cardiovascular events and overall mortality were estimated for each tertile. Predictors of overall mortality and for the development of renal disease progression were analyzed. Results. The median age was 75 years (interquartile range 69–82) and the median eGFRcreat 38 mL/min m2 (interquartile range 33–49). Overall mortality was lower on the first and on the second tertiles of cystatin C than on the third one (HR = 0.060; 95% CI: 0.008–0.447 and HR = 0.094; 95% CI: 0.022–0.406, resp.). Deaths related to the creatinine tertiles followed the same pattern, but differences were not as large. Cardiovascular mortality was lower on the second than on the third cystatin C tertile (HR = 0.198; 95% CI: 0.040–0.987), but it did not show differences on the first and the second creatinine tertiles compared with the third one (HR = 0.126; 95% CI: 0.013–1.265 and HR = 0.403; 95% CI: 0.093–1.740). The only independent predictors of mortality during followup were baseline cystatin C (OR = 0.100; 95% CI: 0.021–0.463) and baseline uric acid (OR = 1.377; 95% CI: 1.070–1.773). Conclusion. Cystatin C may be an alternative to creatinine for detecting a high risk of death and cardiovascular events in a population with CKD. |
| format | Article |
| id | doaj-art-5bd7d7ab8a064fe0ac95bdeb9d35d5a8 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-5bd7d7ab8a064fe0ac95bdeb9d35d5a82025-02-03T06:00:09ZengWileyInternational Journal of Nephrology2090-214X2090-21582014-01-01201410.1155/2014/127943127943Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney DiseaseAna Vigil0Emilia Condés1Luis Vigil2Paloma Gallar3Aniana Oliet4Olimpia Ortega5Isabel Rodriguez6Milagros Ortiz7Juan Carlos Herrero8Carmen Mon9Gabriela Cobo10Juana Jimenez11Department of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Medical Specialties, Psychology and Applied Pedagogy, Universidad European de Madrid, Villaviciosa de Odon, 28670 Madrid, SpainHypertension Unit, Department of Internal Medicine, Hospital Universitario de Mostoles, Móstoles, 28935 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Nephrology, Nephrology Service, Hospital Universitario Severo Ochoa, Avenida. Orellana s/n, Leganés, 28911 Madrid, SpainDepartment of Biochemistry, Hospital Universitario Severo Ochoa, Leganes, 28911 Madrid, SpainBackground. We examine whether cystatin C, a surrogate marker of renal function, could identify patients with chronic kidney disease (CKD) with an increased risk of renal disease progression, death, or cardiovascular events. Methods. Data were obtained for 180 patients, with a diagnosis of chronic renal failure based on serum creatinine estimated glomerular filtration rate (eGFRcreat) <90 mL/min/1.73 m2. This population was grouped in tertiles according to cystatin C and creatinine values at baseline. Cardiovascular events and overall mortality were estimated for each tertile. Predictors of overall mortality and for the development of renal disease progression were analyzed. Results. The median age was 75 years (interquartile range 69–82) and the median eGFRcreat 38 mL/min m2 (interquartile range 33–49). Overall mortality was lower on the first and on the second tertiles of cystatin C than on the third one (HR = 0.060; 95% CI: 0.008–0.447 and HR = 0.094; 95% CI: 0.022–0.406, resp.). Deaths related to the creatinine tertiles followed the same pattern, but differences were not as large. Cardiovascular mortality was lower on the second than on the third cystatin C tertile (HR = 0.198; 95% CI: 0.040–0.987), but it did not show differences on the first and the second creatinine tertiles compared with the third one (HR = 0.126; 95% CI: 0.013–1.265 and HR = 0.403; 95% CI: 0.093–1.740). The only independent predictors of mortality during followup were baseline cystatin C (OR = 0.100; 95% CI: 0.021–0.463) and baseline uric acid (OR = 1.377; 95% CI: 1.070–1.773). Conclusion. Cystatin C may be an alternative to creatinine for detecting a high risk of death and cardiovascular events in a population with CKD.http://dx.doi.org/10.1155/2014/127943 |
| spellingShingle | Ana Vigil Emilia Condés Luis Vigil Paloma Gallar Aniana Oliet Olimpia Ortega Isabel Rodriguez Milagros Ortiz Juan Carlos Herrero Carmen Mon Gabriela Cobo Juana Jimenez Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease International Journal of Nephrology |
| title | Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease |
| title_full | Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease |
| title_fullStr | Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease |
| title_full_unstemmed | Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease |
| title_short | Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease |
| title_sort | cystatin c as a predictor of mortality and cardiovascular events in a population with chronic kidney disease |
| url | http://dx.doi.org/10.1155/2014/127943 |
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