The effects of oleuropein on lung and heart injury in cecal ligation and puncture - induced sepsis
<b>Aim:</b> Sepsis is a fatal serious clinical disorder. The oxidative stress in sepsis plays an important role in the inflammation. Therefore, the effects of oleuropein (OLE) and ceftriaxone (CEFT) on sepsis were investigated in this study.<p> <b>Materials and Methods:</b...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2020-10-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1301 |
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| Summary: | <b>Aim:</b> Sepsis is a fatal serious clinical disorder. The oxidative stress
in sepsis plays an important role in the inflammation. Therefore, the
effects of oleuropein (OLE) and ceftriaxone (CEFT) on sepsis were
investigated in this study.<p>
<b>Materials and Methods:</b> Thirty male rats were divided into five
equal groups: Sham, Sepsis, CEFT, OLE-150 and OLE-300, The
150 mg/kg of ceftriaxone (i.p.), and 150 and 300 mg/kg OLE (p.o.)
were administered to the treatment groups fifteen minutes before
the experiment. After 24 hours, blood samples, lungs and hearts tissues
were taken. The creatine kinase (CK) and lactate dehydrogenase
(LDH) activities in serum, lipid peroxidation (LPO), glutathione
(GSH), superoxide dismutase (SOD) and catalase (CAT) levels were
all determined. In addition, the expressions of the interleukin (IL)-8
in lung and tumor necrosis factor (TNF)-? in heart were pathologically
and immunohistochemically were determined.<p>
<b>Results:</b> Sepsis caused significant increases in CK, LDH, LPO, GSH
and heart CAT activity and caused inhibition of SOD and lung CAT
activity (p<0.001). The OLE significantly decreased the LPO and GSH
levels (p<0.001) and increased the SOD in activity of both tissues
and CAT activity in lung tissue (p<0.001). Moreover, CEFT significantly
decreased the LPO level (p<0.01) and increased tissue SOD
and CAT activities in lung tissue (p<0.001). CK and LDH activities in
serum showed marked decrease in OLE and CEFT groups (p<0.001).<p>
<b>Conclusion:</b> Antioxidant and a notable anti-inflammatory effect of
OLE by reducing IL-8 and TNF-? levels have been stated. Thus, a
strong antioxidant, such as OLE, would be beneficial for the treatment
of sepsis. |
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| ISSN: | 1309-6958 2146-1953 |