Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review
This literature review, in light of the presented case report, explores the complex interplay between gabapentin (GBP), a gamma-aminobutyric acid (GABA) analog, and the hypothalamic–pituitary–adrenal (HPA) axis in patients undergoing major surgical procedures. It specifically investigates the potent...
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MDPI AG
2024-09-01
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| Online Access: | https://www.mdpi.com/1424-8247/17/9/1174 |
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| author | Evmorfia Pechlivanidou Alexandros Chatzikyriakos Maria Anna Zisi Nikolaos Paraskevopoulos Semeli Kaltsa Orestis K. Konstantas Panteleimon Zogakis Aikaterini Catsouli Nick Sekouris Rodanthi E. Margariti |
| author_facet | Evmorfia Pechlivanidou Alexandros Chatzikyriakos Maria Anna Zisi Nikolaos Paraskevopoulos Semeli Kaltsa Orestis K. Konstantas Panteleimon Zogakis Aikaterini Catsouli Nick Sekouris Rodanthi E. Margariti |
| author_sort | Evmorfia Pechlivanidou |
| collection | DOAJ |
| description | This literature review, in light of the presented case report, explores the complex interplay between gabapentin (GBP), a gamma-aminobutyric acid (GABA) analog, and the hypothalamic–pituitary–adrenal (HPA) axis in patients undergoing major surgical procedures. It specifically investigates the potential impact of GBP on cortisol levels, stress responses, and infection risk, illustrated by a detailed clinical case. This review combines a comprehensive literature search with a case report of a 17-year-old male with osteosarcoma who experienced transient adrenal insufficiency and infections while receiving GBP. The case is analyzed in the context of the existing literature on GBP and the HPA axis. The findings highlight the intricate relationship between GBP use, adrenal insufficiency, and infection susceptibility. It underscores the need for further research and clinical vigilance when prescribing GBP to patients with underlying medical conditions, particularly in the context of major surgical procedures. The review underscores the need for further research and clinical vigilance when prescribing GBP, particularly in perioperative settings. In conclusion, GBP’s effects on the HPA axis and immune responses are complex and multifaceted. Clinicians should exercise caution when prescribing GBP, especially for patients with underlying conditions undergoing major surgery. Further research is needed to elucidate the mechanisms of GBP’s influence on cortisol levels and stress responses. |
| format | Article |
| id | doaj-art-5bcf3afb3c1749ae8dd8b8c85f5d5db2 |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-5bcf3afb3c1749ae8dd8b8c85f5d5db22025-08-20T01:55:46ZengMDPI AGPharmaceuticals1424-82472024-09-01179117410.3390/ph17091174Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature ReviewEvmorfia Pechlivanidou0Alexandros Chatzikyriakos1Maria Anna Zisi2Nikolaos Paraskevopoulos3Semeli Kaltsa4Orestis K. Konstantas5Panteleimon Zogakis6Aikaterini Catsouli7Nick Sekouris8Rodanthi E. Margariti91st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, GreeceThis literature review, in light of the presented case report, explores the complex interplay between gabapentin (GBP), a gamma-aminobutyric acid (GABA) analog, and the hypothalamic–pituitary–adrenal (HPA) axis in patients undergoing major surgical procedures. It specifically investigates the potential impact of GBP on cortisol levels, stress responses, and infection risk, illustrated by a detailed clinical case. This review combines a comprehensive literature search with a case report of a 17-year-old male with osteosarcoma who experienced transient adrenal insufficiency and infections while receiving GBP. The case is analyzed in the context of the existing literature on GBP and the HPA axis. The findings highlight the intricate relationship between GBP use, adrenal insufficiency, and infection susceptibility. It underscores the need for further research and clinical vigilance when prescribing GBP to patients with underlying medical conditions, particularly in the context of major surgical procedures. The review underscores the need for further research and clinical vigilance when prescribing GBP, particularly in perioperative settings. In conclusion, GBP’s effects on the HPA axis and immune responses are complex and multifaceted. Clinicians should exercise caution when prescribing GBP, especially for patients with underlying conditions undergoing major surgery. Further research is needed to elucidate the mechanisms of GBP’s influence on cortisol levels and stress responses.https://www.mdpi.com/1424-8247/17/9/1174gabapentinadrenal insufficiencyinfectionsHPA axisstress responses<i>Staphylococcus xylosus</i> |
| spellingShingle | Evmorfia Pechlivanidou Alexandros Chatzikyriakos Maria Anna Zisi Nikolaos Paraskevopoulos Semeli Kaltsa Orestis K. Konstantas Panteleimon Zogakis Aikaterini Catsouli Nick Sekouris Rodanthi E. Margariti Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review Pharmaceuticals gabapentin adrenal insufficiency infections HPA axis stress responses <i>Staphylococcus xylosus</i> |
| title | Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review |
| title_full | Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review |
| title_fullStr | Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review |
| title_full_unstemmed | Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review |
| title_short | Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review |
| title_sort | gabapentin induced adrenal insufficiency the hypothalamic pituitary adrenal axis stress misresponse and risk of infection a case report and literature review |
| topic | gabapentin adrenal insufficiency infections HPA axis stress responses <i>Staphylococcus xylosus</i> |
| url | https://www.mdpi.com/1424-8247/17/9/1174 |
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