Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective
<i>Background and Objectives:</i> The rapid growth of the number of advanced Parkinson’s disease (PD) patients has caused a significant increase in the use of device-aided therapies (DATs), including levodopa–carbidopa intestinal gel (LCIG) and continuous subcutaneous apomorphine infusio...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/1/27 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587993113690112 |
|---|---|
| author | Julia Węgrzynek-Gallina Tomasz Chmiela Michał Borończyk Aleksandra Buczek Patrycja Hudzińska Hubert Bigajski Damian Waksmundzki Justyna Gawryluk Joanna Siuda |
| author_facet | Julia Węgrzynek-Gallina Tomasz Chmiela Michał Borończyk Aleksandra Buczek Patrycja Hudzińska Hubert Bigajski Damian Waksmundzki Justyna Gawryluk Joanna Siuda |
| author_sort | Julia Węgrzynek-Gallina |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The rapid growth of the number of advanced Parkinson’s disease (PD) patients has caused a significant increase in the use of device-aided therapies (DATs), including levodopa–carbidopa intestinal gel (LCIG) and continuous subcutaneous apomorphine infusion (CSAI). The objective of this study was to evaluate patients’ satisfaction and the factors influencing preferences for CSAI and LCIG. <i>Materials and Methods:</i> The research focused on individuals diagnosed with advanced PD undergoing DAT at the Neurology Department of the University Hospital in Katowice. A telephone survey conducted between June and July 2024 evaluated the experiences of patients with LCIG and CSAI. The Parkinson’s Disease Questionnaire (PDQ-8) and the Stress Scale for Family Caregivers (BSFC-s) were applied. Based on medical record data comprising reasons for the exclusion of individuals, disease-related and treatment data were collected. <i>Results:</i> Among the original cohort of 64 patients, 50 completed the survey, including 31 who might choose between infusion therapies. The average patient ages were 70.6 ± 4.7 (CSAI) and 71.2 ± 7.2 years (LCIG), with disease durations of 15 (IQR: 12–19) and 18 (IQR: 13–19) years, respectively. LCIG patients presented higher PDQ-8 scores (20 (IQR: 13–27) vs. 13 (IQR: 6–19), <i>p</i> = 0.008), and higher BSFC-s scores (19 (IQR: 12–21) vs. 9 (IQR: 2.5–13), <i>p</i> = 0.011). Furthermore, significant factors influencing patient preferences included fear of surgery (75% vs. 36.8%, <i>p</i> = 0.043) and concerns about DAT safety (83.3% vs. 47.4%, <i>p</i> = 0.049). <i>Conclusions:</i> LCIG and CSAI therapies offer benefits and disadvantages, with safety concerns and fear of surgery seeming to be decisive in the decision-making process. |
| format | Article |
| id | doaj-art-5bce610bdf3940128270821a239b492f |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-5bce610bdf3940128270821a239b492f2025-01-24T13:40:18ZengMDPI AGMedicina1010-660X1648-91442024-12-016112710.3390/medicina61010027Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient PerspectiveJulia Węgrzynek-Gallina0Tomasz Chmiela1Michał Borończyk2Aleksandra Buczek3Patrycja Hudzińska4Hubert Bigajski5Damian Waksmundzki6Justyna Gawryluk7Joanna Siuda8Department of Neurology, Faculty of Medical Sciences in Katowice, University Clinical Centre Prof K. Gibinski, Medical University of Silesia, 14 Medykow St. 40-752 Katowice, PolandDepartment of Neurology, Faculty of Medical Sciences in Katowice, University Clinical Centre Prof K. Gibinski, Medical University of Silesia, 14 Medykow St. 40-752 Katowice, PolandDepartment of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 45/47 Ziolowa St., 40-635 Katowice, PolandStudents’ Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 14 Medykow St, 40-752 Katowice, PolandStudents’ Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 14 Medykow St, 40-752 Katowice, PolandStudents’ Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 14 Medykow St, 40-752 Katowice, PolandStudents’ Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 14 Medykow St, 40-752 Katowice, PolandDepartment of Neurology, Faculty of Medical Sciences in Katowice, University Clinical Centre Prof K. Gibinski, Medical University of Silesia, 14 Medykow St. 40-752 Katowice, PolandDepartment of Neurology, Faculty of Medical Sciences in Katowice, University Clinical Centre Prof K. Gibinski, Medical University of Silesia, 14 Medykow St. 40-752 Katowice, Poland<i>Background and Objectives:</i> The rapid growth of the number of advanced Parkinson’s disease (PD) patients has caused a significant increase in the use of device-aided therapies (DATs), including levodopa–carbidopa intestinal gel (LCIG) and continuous subcutaneous apomorphine infusion (CSAI). The objective of this study was to evaluate patients’ satisfaction and the factors influencing preferences for CSAI and LCIG. <i>Materials and Methods:</i> The research focused on individuals diagnosed with advanced PD undergoing DAT at the Neurology Department of the University Hospital in Katowice. A telephone survey conducted between June and July 2024 evaluated the experiences of patients with LCIG and CSAI. The Parkinson’s Disease Questionnaire (PDQ-8) and the Stress Scale for Family Caregivers (BSFC-s) were applied. Based on medical record data comprising reasons for the exclusion of individuals, disease-related and treatment data were collected. <i>Results:</i> Among the original cohort of 64 patients, 50 completed the survey, including 31 who might choose between infusion therapies. The average patient ages were 70.6 ± 4.7 (CSAI) and 71.2 ± 7.2 years (LCIG), with disease durations of 15 (IQR: 12–19) and 18 (IQR: 13–19) years, respectively. LCIG patients presented higher PDQ-8 scores (20 (IQR: 13–27) vs. 13 (IQR: 6–19), <i>p</i> = 0.008), and higher BSFC-s scores (19 (IQR: 12–21) vs. 9 (IQR: 2.5–13), <i>p</i> = 0.011). Furthermore, significant factors influencing patient preferences included fear of surgery (75% vs. 36.8%, <i>p</i> = 0.043) and concerns about DAT safety (83.3% vs. 47.4%, <i>p</i> = 0.049). <i>Conclusions:</i> LCIG and CSAI therapies offer benefits and disadvantages, with safety concerns and fear of surgery seeming to be decisive in the decision-making process.https://www.mdpi.com/1648-9144/61/1/27Parkinson’s diseaseinfusion therapieslevodopa–carbidopa intestinal gelcontinuous subcutaneous apomorphine infusionpatients’ preferences |
| spellingShingle | Julia Węgrzynek-Gallina Tomasz Chmiela Michał Borończyk Aleksandra Buczek Patrycja Hudzińska Hubert Bigajski Damian Waksmundzki Justyna Gawryluk Joanna Siuda Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective Medicina Parkinson’s disease infusion therapies levodopa–carbidopa intestinal gel continuous subcutaneous apomorphine infusion patients’ preferences |
| title | Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective |
| title_full | Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective |
| title_fullStr | Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective |
| title_full_unstemmed | Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective |
| title_short | Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective |
| title_sort | satisfaction and preferences for infusion therapies in advanced parkinson s disease patient perspective |
| topic | Parkinson’s disease infusion therapies levodopa–carbidopa intestinal gel continuous subcutaneous apomorphine infusion patients’ preferences |
| url | https://www.mdpi.com/1648-9144/61/1/27 |
| work_keys_str_mv | AT juliawegrzynekgallina satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT tomaszchmiela satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT michałboronczyk satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT aleksandrabuczek satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT patrycjahudzinska satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT hubertbigajski satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT damianwaksmundzki satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT justynagawryluk satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective AT joannasiuda satisfactionandpreferencesforinfusiontherapiesinadvancedparkinsonsdiseasepatientperspective |