Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature
ABSTRACT: Ustekinumab is a first-line drug for Crohn's disease. However, little is known about its potential adverse effects on renal function. We present the case of a 42-year-old man with Crohn's disease who developed chronic renal dysfunction during ustekinumab treatment, which resolved...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Therapeutic Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0011393X24000237 |
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| author | Yuge Wei, Ms Gechong Ruan, MD Yan Qin, MD Xiaoyin Bai, MD Hong Yang, MD |
| author_facet | Yuge Wei, Ms Gechong Ruan, MD Yan Qin, MD Xiaoyin Bai, MD Hong Yang, MD |
| author_sort | Yuge Wei, Ms |
| collection | DOAJ |
| description | ABSTRACT: Ustekinumab is a first-line drug for Crohn's disease. However, little is known about its potential adverse effects on renal function. We present the case of a 42-year-old man with Crohn's disease who developed chronic renal dysfunction during ustekinumab treatment, which resolved after discontinuing ustekinumab. The findings underscore the importance of close monitoring of renal function in patients receiving ustekinumab, particularly those with preexisting kidney disease or risk factors for renal dysfunction. |
| format | Article |
| id | doaj-art-5bcd1853395d456eacc010f90b515c0a |
| institution | OA Journals |
| issn | 0011-393X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Therapeutic Research |
| spelling | doaj-art-5bcd1853395d456eacc010f90b515c0a2025-08-20T02:38:05ZengElsevierCurrent Therapeutic Research0011-393X2024-01-0110110075310.1016/j.curtheres.2024.100753Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the LiteratureYuge Wei, Ms0Gechong Ruan, MD1Yan Qin, MD2Xiaoyin Bai, MD3Hong Yang, MD44+4 Medical Doctor Program, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Address correspondence to: Hong Yang, MD, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 5, Dongdansantiao, Dongcheng District, Beijing 100730, China.ABSTRACT: Ustekinumab is a first-line drug for Crohn's disease. However, little is known about its potential adverse effects on renal function. We present the case of a 42-year-old man with Crohn's disease who developed chronic renal dysfunction during ustekinumab treatment, which resolved after discontinuing ustekinumab. The findings underscore the importance of close monitoring of renal function in patients receiving ustekinumab, particularly those with preexisting kidney disease or risk factors for renal dysfunction.http://www.sciencedirect.com/science/article/pii/S0011393X24000237Crohn's diseaseRenal insufficiencyUstekinumab |
| spellingShingle | Yuge Wei, Ms Gechong Ruan, MD Yan Qin, MD Xiaoyin Bai, MD Hong Yang, MD Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature Current Therapeutic Research Crohn's disease Renal insufficiency Ustekinumab |
| title | Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature |
| title_full | Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature |
| title_fullStr | Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature |
| title_full_unstemmed | Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature |
| title_short | Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature |
| title_sort | renal dysfunction in a patient with crohn s disease during ustekinumab treatment a case report and review of the literature |
| topic | Crohn's disease Renal insufficiency Ustekinumab |
| url | http://www.sciencedirect.com/science/article/pii/S0011393X24000237 |
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