EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS
The purpose of the study was to evaluate the nosological structure of central nervous system (CNS) tumors and the role of immunohistochemical assay in verification of their histogenesis.Material and methods. 162 biopsy and surgical specimens of CNS tumors obtained from neurosurgical departments of h...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/52 |
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| author | А. P. Nadeev V. А. Zhukova М. А. Kozyaev М. А. Travin К. Е. Yatsenko |
| author_facet | А. P. Nadeev V. А. Zhukova М. А. Kozyaev М. А. Travin К. Е. Yatsenko |
| author_sort | А. P. Nadeev |
| collection | DOAJ |
| description | The purpose of the study was to evaluate the nosological structure of central nervous system (CNS) tumors and the role of immunohistochemical assay in verification of their histogenesis.Material and methods. 162 biopsy and surgical specimens of CNS tumors obtained from neurosurgical departments of hospitals in Novosibirsk and Siberian Federal District in the period 2004–2013 were studied.Results. In the structure of primary CNS tumors, astrocytic tumors were the most common (47.9 %) followed by meningeal tumors (9.3 %), and oligodendroglial tumors (6.3 %) located predominantly in in the cerebral hemispheres of the brain (81 %). CNS metastases occurred on 11% of cases, there were mainly malignant epithelial tumor metastases. Inflammatory pseudotumors were observed in 3.1 % of cases. The use of immunohistochemistry with a broad panel of antibodies, mainly: pan-cytokeratin, vimentin, leukocyte common antigen, epithelial membrane antigen, glial fibrillary acidic protein allowed the histogenesis of CNS tumors to be clarified in 29.6 % of cases. |
| format | Article |
| id | doaj-art-5bc6a91df1804ef990537cad34be4b4d |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-5bc6a91df1804ef990537cad34be4b4d2025-08-20T03:35:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-0103515552EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORSА. P. Nadeev0V. А. Zhukova1М. А. Kozyaev2М. А. Travin3К. Е. Yatsenko4Novosibirsk State Medical University, Novosibirsk52, Kkrasny Prospect, 630091-Novosibirsk52, Kkrasny Prospect, 630091-Novosibirsk52, Kkrasny Prospect, 630091-Novosibirsk52, Kkrasny Prospect, 630091-NovosibirskThe purpose of the study was to evaluate the nosological structure of central nervous system (CNS) tumors and the role of immunohistochemical assay in verification of their histogenesis.Material and methods. 162 biopsy and surgical specimens of CNS tumors obtained from neurosurgical departments of hospitals in Novosibirsk and Siberian Federal District in the period 2004–2013 were studied.Results. In the structure of primary CNS tumors, astrocytic tumors were the most common (47.9 %) followed by meningeal tumors (9.3 %), and oligodendroglial tumors (6.3 %) located predominantly in in the cerebral hemispheres of the brain (81 %). CNS metastases occurred on 11% of cases, there were mainly malignant epithelial tumor metastases. Inflammatory pseudotumors were observed in 3.1 % of cases. The use of immunohistochemistry with a broad panel of antibodies, mainly: pan-cytokeratin, vimentin, leukocyte common antigen, epithelial membrane antigen, glial fibrillary acidic protein allowed the histogenesis of CNS tumors to be clarified in 29.6 % of cases.https://www.siboncoj.ru/jour/article/view/52central nervous system tumors, immunohistochemical assay |
| spellingShingle | А. P. Nadeev V. А. Zhukova М. А. Kozyaev М. А. Travin К. Е. Yatsenko EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS Сибирский онкологический журнал central nervous system tumors, immunohistochemical assay |
| title | EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS |
| title_full | EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS |
| title_fullStr | EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS |
| title_full_unstemmed | EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS |
| title_short | EXPERIENCE IN USING IMMUNOHISTOCHEMICAL METHOD IN DIFFERENTIAL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUMORS |
| title_sort | experience in using immunohistochemical method in differential diagnosis of central nervous system tumors |
| topic | central nervous system tumors, immunohistochemical assay |
| url | https://www.siboncoj.ru/jour/article/view/52 |
| work_keys_str_mv | AT apnadeev experienceinusingimmunohistochemicalmethodindifferentialdiagnosisofcentralnervoussystemtumors AT vazhukova experienceinusingimmunohistochemicalmethodindifferentialdiagnosisofcentralnervoussystemtumors AT makozyaev experienceinusingimmunohistochemicalmethodindifferentialdiagnosisofcentralnervoussystemtumors AT matravin experienceinusingimmunohistochemicalmethodindifferentialdiagnosisofcentralnervoussystemtumors AT keyatsenko experienceinusingimmunohistochemicalmethodindifferentialdiagnosisofcentralnervoussystemtumors |