Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring
Abstract Background Biosensors are tools that are products of amalgamation of biological constituents and physicochemical elements so as to detect analytes, based on signal production which is measurable. Thus here we can see an assimilation of biology and microelectronics. Keeping a track of bioche...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | Bulletin of the National Research Centre |
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| Online Access: | https://doi.org/10.1186/s42269-025-01308-4 |
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| author | Rosaline Mishra Sakshi Minocha Radha Goel Praveen Kumar Gaur Kanak Lata Rashmi Singh |
| author_facet | Rosaline Mishra Sakshi Minocha Radha Goel Praveen Kumar Gaur Kanak Lata Rashmi Singh |
| author_sort | Rosaline Mishra |
| collection | DOAJ |
| description | Abstract Background Biosensors are tools that are products of amalgamation of biological constituents and physicochemical elements so as to detect analytes, based on signal production which is measurable. Thus here we can see an assimilation of biology and microelectronics. Keeping a track of biochemical processes in a human system is essential; thus, there is an increasing need for extremely sensitive and economical devices which can make precise diagnosis and personalised medication treatment possible. Objective This review focuses upon the novel innovations in the field of biosensors, namely making use of nanotechnology in the form of nanomaterials such as graphene, gold nanoparticles, quantum dots, and sulphur-containing nanomaterials. Method A thorough evaluation of the literature was done. Databases like SciFinder, ScienceDirect, PubMed, Google, Google Scholar, and the Egyptian Knowledge Bank were used to find pertinent publications. More than 500 articles and databases were studied to constitute this paper. The accuracy of the retrieved data was carefully reviewed and cross-checked. Selection of nanomaterial for the creation of biosensors was studied: Nanomaterials (such as graphene, carbon nanotubes, and quantum dots) according to their special qualities (such as high surface area, biocompatibility, and sensitivity) were selected. A thorough study on biomolecular integration was done: To gain knowledge on extremely sensitive and selective biosensors for target analytes, integrate particular biomolecules (such as enzymes, aptamers, and antibodies) onto nanomaterials and also data on manufacturing of sensors were utilised; sophisticated manufacturing methods (such as self-assembly and lithography) to build biosensors that have exact control over the arrangement of nanomaterials and biomolecules were studied. Signal Transduction: To transform biomolecular interactions into quantifiable signals, effectively develop signal transduction systems (e.g. electrochemical, optical, mechanical). Real-time Monitoring: For ongoing, non-invasive health monitoring, include biosensors with wearable technology or point-of-care diagnostics. Data analysis: To interpret and analyse biosensor signals for precise and rapid health evaluations, apply machine learning techniques and sophisticated data analysis algorithms. Result After applying article selection criteria and reviewing the quality of the methodology, a total of 200 articles were selected to be included in the review. Conclusion The combination of biology and nanotechnology, or "bioconvergence", has enormous potential to transform healthcare. Biosensors for real-time, non-invasive health monitoring can be built by utilising the distinct qualities of nanomaterials and the specificity of biomolecules. This technology could lead to a more efficient and individualised healthcare system by improving disease diagnosis, treatment, and overall patient outcomes. |
| format | Article |
| id | doaj-art-5bc650d7e5e146768026cd61544fb08b |
| institution | DOAJ |
| issn | 2522-8307 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj-art-5bc650d7e5e146768026cd61544fb08b2025-08-20T02:43:10ZengSpringerOpenBulletin of the National Research Centre2522-83072025-02-0149111410.1186/s42269-025-01308-4Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoringRosaline Mishra0Sakshi Minocha1Radha Goel2Praveen Kumar Gaur3Kanak Lata4Rashmi Singh5Metro College of Health Sciences and ResearchMetro College of Health Sciences and ResearchLloyd Institute of Management & TechnologyMetro College of Health Sciences and ResearchMetro College of Health Sciences and ResearchMetro College of Health Sciences and ResearchAbstract Background Biosensors are tools that are products of amalgamation of biological constituents and physicochemical elements so as to detect analytes, based on signal production which is measurable. Thus here we can see an assimilation of biology and microelectronics. Keeping a track of biochemical processes in a human system is essential; thus, there is an increasing need for extremely sensitive and economical devices which can make precise diagnosis and personalised medication treatment possible. Objective This review focuses upon the novel innovations in the field of biosensors, namely making use of nanotechnology in the form of nanomaterials such as graphene, gold nanoparticles, quantum dots, and sulphur-containing nanomaterials. Method A thorough evaluation of the literature was done. Databases like SciFinder, ScienceDirect, PubMed, Google, Google Scholar, and the Egyptian Knowledge Bank were used to find pertinent publications. More than 500 articles and databases were studied to constitute this paper. The accuracy of the retrieved data was carefully reviewed and cross-checked. Selection of nanomaterial for the creation of biosensors was studied: Nanomaterials (such as graphene, carbon nanotubes, and quantum dots) according to their special qualities (such as high surface area, biocompatibility, and sensitivity) were selected. A thorough study on biomolecular integration was done: To gain knowledge on extremely sensitive and selective biosensors for target analytes, integrate particular biomolecules (such as enzymes, aptamers, and antibodies) onto nanomaterials and also data on manufacturing of sensors were utilised; sophisticated manufacturing methods (such as self-assembly and lithography) to build biosensors that have exact control over the arrangement of nanomaterials and biomolecules were studied. Signal Transduction: To transform biomolecular interactions into quantifiable signals, effectively develop signal transduction systems (e.g. electrochemical, optical, mechanical). Real-time Monitoring: For ongoing, non-invasive health monitoring, include biosensors with wearable technology or point-of-care diagnostics. Data analysis: To interpret and analyse biosensor signals for precise and rapid health evaluations, apply machine learning techniques and sophisticated data analysis algorithms. Result After applying article selection criteria and reviewing the quality of the methodology, a total of 200 articles were selected to be included in the review. Conclusion The combination of biology and nanotechnology, or "bioconvergence", has enormous potential to transform healthcare. Biosensors for real-time, non-invasive health monitoring can be built by utilising the distinct qualities of nanomaterials and the specificity of biomolecules. This technology could lead to a more efficient and individualised healthcare system by improving disease diagnosis, treatment, and overall patient outcomes.https://doi.org/10.1186/s42269-025-01308-4NanomaterialsPolymersQuantum dotsNanobiosensors |
| spellingShingle | Rosaline Mishra Sakshi Minocha Radha Goel Praveen Kumar Gaur Kanak Lata Rashmi Singh Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring Bulletin of the National Research Centre Nanomaterials Polymers Quantum dots Nanobiosensors |
| title | Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring |
| title_full | Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring |
| title_fullStr | Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring |
| title_full_unstemmed | Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring |
| title_short | Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring |
| title_sort | bioconvergence advancing biosensors with nanotechnology for real time health monitoring |
| topic | Nanomaterials Polymers Quantum dots Nanobiosensors |
| url | https://doi.org/10.1186/s42269-025-01308-4 |
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