Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark
In vivo clinical trials involving the administration of crude extracts of Cissus populnea to male subjects (normospermic, oligospermic, and azoopermic) in a 72-day study revealed that continuous exposure of the subjects to the extracts over this period did not significantly (p ≤ 0.05) alter sperm co...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.343 |
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| author | Anthony B. Ojekale Oladipupo A. Lawal Adedoyin K. Lasisi Tajudeen I. Adeleke |
| author_facet | Anthony B. Ojekale Oladipupo A. Lawal Adedoyin K. Lasisi Tajudeen I. Adeleke |
| author_sort | Anthony B. Ojekale |
| collection | DOAJ |
| description | In vivo clinical trials involving the administration of crude extracts of Cissus populnea to male subjects (normospermic, oligospermic, and azoopermic) in a 72-day study revealed that continuous exposure of the subjects to the extracts over this period did not significantly (p ≤ 0.05) alter sperm count, morphology, motility, or volume. Antimicrobial screening of the extract against some selected microbial isolates secondarily implicated in male infertility revealed total inactivity against the microbial isolates screened, i.e., Staphylococcus aureus, Salmonella paratyphi, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Candida albicans, and Klebsiella sp. Phytochemistry revealed the presence of tannins, flavonoids, saponins, and steroids. The presence of these secondary metabolites was confirmed by thin layer chromatography. We conclude that oral administration of aqueous extracts of the stem bark of Cisssus populnea over a 72-day period to human subjects apparently had no fertility enhancement effects on sperm parameters monitored in this study. |
| format | Article |
| id | doaj-art-5bc544f2546d4477b01e75f1d80cabbb |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5bc544f2546d4477b01e75f1d80cabbb2025-08-20T03:34:28ZengWileyThe Scientific World Journal1537-744X2006-01-0162140214610.1100/tsw.2006.343Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem BarkAnthony B. Ojekale0Oladipupo A. Lawal1Adedoyin K. Lasisi2Tajudeen I. Adeleke3Department of Biochemistry, Lagos State University, Ojo, Apapa, NigeriaDepartment of Chemistry, Lagos State University, Ojo, P.M.B.1087, Apapa, NigeriaDepartment of Biochemistry, Lagos State University, Ojo, Apapa, NigeriaDepartment of Pharmacognosy, College of Medicine, University of Lagos, Idi- Araba, Lagos, NigeriaIn vivo clinical trials involving the administration of crude extracts of Cissus populnea to male subjects (normospermic, oligospermic, and azoopermic) in a 72-day study revealed that continuous exposure of the subjects to the extracts over this period did not significantly (p ≤ 0.05) alter sperm count, morphology, motility, or volume. Antimicrobial screening of the extract against some selected microbial isolates secondarily implicated in male infertility revealed total inactivity against the microbial isolates screened, i.e., Staphylococcus aureus, Salmonella paratyphi, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Candida albicans, and Klebsiella sp. Phytochemistry revealed the presence of tannins, flavonoids, saponins, and steroids. The presence of these secondary metabolites was confirmed by thin layer chromatography. We conclude that oral administration of aqueous extracts of the stem bark of Cisssus populnea over a 72-day period to human subjects apparently had no fertility enhancement effects on sperm parameters monitored in this study.http://dx.doi.org/10.1100/tsw.2006.343 |
| spellingShingle | Anthony B. Ojekale Oladipupo A. Lawal Adedoyin K. Lasisi Tajudeen I. Adeleke Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark The Scientific World Journal |
| title | Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark |
| title_full | Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark |
| title_fullStr | Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark |
| title_full_unstemmed | Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark |
| title_short | Phytochemisty and Spermatogenic Potentials of Aqueous Extract of Cissus populnea (Guill. and Per) Stem Bark |
| title_sort | phytochemisty and spermatogenic potentials of aqueous extract of cissus populnea guill and per stem bark |
| url | http://dx.doi.org/10.1100/tsw.2006.343 |
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