First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio)
To protect against UV light, organic UV filters (UVFs) are widely used in sunscreen and various consumer products. Concerns regarding the potential health impacts of UVFs have been raised, however, information is mostly limited to their endocrine disruptions. The present study aims to investigate ne...
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Elsevier
2025-11-01
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| Series: | Journal of Hazardous Materials Letters |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666911025000036 |
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| author | Ba Reum Kwon Gowoon Lee Inae Lee Ah-Reum Jo Jeonghwan Lee Na-Youn Park Younglim Kho Jung Pyo Lee Kyungho Choi |
| author_facet | Ba Reum Kwon Gowoon Lee Inae Lee Ah-Reum Jo Jeonghwan Lee Na-Youn Park Younglim Kho Jung Pyo Lee Kyungho Choi |
| author_sort | Ba Reum Kwon |
| collection | DOAJ |
| description | To protect against UV light, organic UV filters (UVFs) are widely used in sunscreen and various consumer products. Concerns regarding the potential health impacts of UVFs have been raised, however, information is mostly limited to their endocrine disruptions. The present study aims to investigate nephrotoxic potentials of four major organic UVFs, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), using a zebrafish model at different life stages. Test UVFs were applied during early (0–30 days post-fertilization (dpf)), and adult life stage (> 6 months old, 21 d exposure), and investigated for alterations in gene expression and/or kidney function. In juvenile fish (30 dpf), early life stage exposure to BP-3 and OMC caused significant induction of proteinuria. Moreover, regardless of life stage, key genes (wt1a, podocin, nephrin, cdh17, sim1a, and kim-1) responsible for kidney structure and function showed transcriptional alterations that support nephrotoxic potentials of the test UVFs. Our results demonstrate that exposure to widely used organic UVFs could impair normal biological processes for maintaining kidney health during both life stages. Considering the widespread use of organic UVFs among the general human population, the implication of this nephrotoxic potential warrants further investigation. |
| format | Article |
| id | doaj-art-5bc173a5f3b5437c945c1d3b0deb7f37 |
| institution | DOAJ |
| issn | 2666-9110 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Hazardous Materials Letters |
| spelling | doaj-art-5bc173a5f3b5437c945c1d3b0deb7f372025-08-20T02:54:50ZengElsevierJournal of Hazardous Materials Letters2666-91102025-11-01610014310.1016/j.hazl.2025.100143First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio)Ba Reum Kwon0Gowoon Lee1Inae Lee2Ah-Reum Jo3Jeonghwan Lee4Na-Youn Park5Younglim Kho6Jung Pyo Lee7Kyungho Choi8Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Safety Engineering, Korea National University of Transportation, Chungbuk 27469, Republic of KoreaDepartment of Public Health, Keimyung University, Daegu 42601, Republic of KoreaGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Republic of KoreaDepartment of Health, Environment & Safety, Eulji University, Seongnam 13135, Republic of KoreaDepartment of Health, Environment & Safety, Eulji University, Seongnam 13135, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Republic of KoreaGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea; Corresponding author.To protect against UV light, organic UV filters (UVFs) are widely used in sunscreen and various consumer products. Concerns regarding the potential health impacts of UVFs have been raised, however, information is mostly limited to their endocrine disruptions. The present study aims to investigate nephrotoxic potentials of four major organic UVFs, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), using a zebrafish model at different life stages. Test UVFs were applied during early (0–30 days post-fertilization (dpf)), and adult life stage (> 6 months old, 21 d exposure), and investigated for alterations in gene expression and/or kidney function. In juvenile fish (30 dpf), early life stage exposure to BP-3 and OMC caused significant induction of proteinuria. Moreover, regardless of life stage, key genes (wt1a, podocin, nephrin, cdh17, sim1a, and kim-1) responsible for kidney structure and function showed transcriptional alterations that support nephrotoxic potentials of the test UVFs. Our results demonstrate that exposure to widely used organic UVFs could impair normal biological processes for maintaining kidney health during both life stages. Considering the widespread use of organic UVFs among the general human population, the implication of this nephrotoxic potential warrants further investigation.http://www.sciencedirect.com/science/article/pii/S2666911025000036UV filtersProteinuriaPodocyteKidney toxicityZebrafish |
| spellingShingle | Ba Reum Kwon Gowoon Lee Inae Lee Ah-Reum Jo Jeonghwan Lee Na-Youn Park Younglim Kho Jung Pyo Lee Kyungho Choi First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) Journal of Hazardous Materials Letters UV filters Proteinuria Podocyte Kidney toxicity Zebrafish |
| title | First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) |
| title_full | First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) |
| title_fullStr | First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) |
| title_full_unstemmed | First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) |
| title_short | First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) |
| title_sort | first snapshot comparison of nephrotoxic potentials of four common organic uv filters in juvenile and adult zebrafish danio rerio |
| topic | UV filters Proteinuria Podocyte Kidney toxicity Zebrafish |
| url | http://www.sciencedirect.com/science/article/pii/S2666911025000036 |
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