Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure

Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure

Abstract The prevailing view of fibulin-4 deficient mice is that the cardiac phenotype is the result of aortic and/or valvular disease. In the present study, we have tested whether the cardiac phenotype is, at least in part, the consequence of primary cardiac effects of fibulin-4. We have found fibu...

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Main Authors: E. D. van Deel, M. Snelders, N. van Vliet, L. te Riet, T. P. P. van den Bosch, L. R. Fiedler, A. C. C. van Spreeuwel, N. A. M. Bax, N. Boontje, C. M. Halabi, T. Sasaki, D. P. Reinhardt, J. van der Velden, C.V.C. Bouten, J. H. von der Thüsen, A. H. J. Danser, D. J. Duncker, M. D. Schneider, I. van der Pluijm, J. Essers
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08087-8
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