Role of heat shock protein in radiation-induced effect and related potential clinical application
Heat shock protein (HSP), as an intracellular chaperone, is significantly upregulated when cells are exposed to radiation and other stress environments, playing an important role in cell self-protection. This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Radiation Medicine and Protection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666555724001175 |
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| author | Ying Xu Wentao Hu Guangming Zhou |
| author_facet | Ying Xu Wentao Hu Guangming Zhou |
| author_sort | Ying Xu |
| collection | DOAJ |
| description | Heat shock protein (HSP), as an intracellular chaperone, is significantly upregulated when cells are exposed to radiation and other stress environments, playing an important role in cell self-protection. This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but also provides a strategy for cancer cells to reduce their sensitivity to radiation and escape treatment. More research is needed to clarify the specific mechanism of HSP in radiotherapy and how to better use its biological effects for clinical individualized treatment. This paper reviews the biological effects of HSP under radiation and the latest research progress of combined radiation and HSP inhibitors or hyperthermia, in the hope of having a more comprehensive understanding of its mechanism in physiological processes such as cell survival, apoptosis, inflammation, immune response, as well as radiation response, which will help to enhance the therapeutic effect and to provide more effective and safer radiotherapy for cancer patients in the future. |
| format | Article |
| id | doaj-art-5bbbc73348cd41ab9ef093b91d4e89c9 |
| institution | Kabale University |
| issn | 2666-5557 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiation Medicine and Protection |
| spelling | doaj-art-5bbbc73348cd41ab9ef093b91d4e89c92025-02-12T05:32:53ZengElsevierRadiation Medicine and Protection2666-55572025-02-01615160Role of heat shock protein in radiation-induced effect and related potential clinical applicationYing Xu0Wentao Hu1Guangming Zhou2State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, ChinaCorresponding author.; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, ChinaCorresponding author.; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, ChinaHeat shock protein (HSP), as an intracellular chaperone, is significantly upregulated when cells are exposed to radiation and other stress environments, playing an important role in cell self-protection. This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but also provides a strategy for cancer cells to reduce their sensitivity to radiation and escape treatment. More research is needed to clarify the specific mechanism of HSP in radiotherapy and how to better use its biological effects for clinical individualized treatment. This paper reviews the biological effects of HSP under radiation and the latest research progress of combined radiation and HSP inhibitors or hyperthermia, in the hope of having a more comprehensive understanding of its mechanism in physiological processes such as cell survival, apoptosis, inflammation, immune response, as well as radiation response, which will help to enhance the therapeutic effect and to provide more effective and safer radiotherapy for cancer patients in the future.http://www.sciencedirect.com/science/article/pii/S2666555724001175Heat shock proteinRadiation resistanceRadiotherapyInhibitorHyperthermia |
| spellingShingle | Ying Xu Wentao Hu Guangming Zhou Role of heat shock protein in radiation-induced effect and related potential clinical application Radiation Medicine and Protection Heat shock protein Radiation resistance Radiotherapy Inhibitor Hyperthermia |
| title | Role of heat shock protein in radiation-induced effect and related potential clinical application |
| title_full | Role of heat shock protein in radiation-induced effect and related potential clinical application |
| title_fullStr | Role of heat shock protein in radiation-induced effect and related potential clinical application |
| title_full_unstemmed | Role of heat shock protein in radiation-induced effect and related potential clinical application |
| title_short | Role of heat shock protein in radiation-induced effect and related potential clinical application |
| title_sort | role of heat shock protein in radiation induced effect and related potential clinical application |
| topic | Heat shock protein Radiation resistance Radiotherapy Inhibitor Hyperthermia |
| url | http://www.sciencedirect.com/science/article/pii/S2666555724001175 |
| work_keys_str_mv | AT yingxu roleofheatshockproteininradiationinducedeffectandrelatedpotentialclinicalapplication AT wentaohu roleofheatshockproteininradiationinducedeffectandrelatedpotentialclinicalapplication AT guangmingzhou roleofheatshockproteininradiationinducedeffectandrelatedpotentialclinicalapplication |