Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series
Ovarian carcinosarcoma (MMMT—malignant mixed Müllerian tumors) is highly aggressive, rare tumor, affecting postmenopausal women with the incidence peak in the sixth decade with significant morbidity and mortality. Uterine carcinosarcomas are rare tumors comprising less than 5% of uterine malignancie...
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1658_24 |
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| author | Thamilselvi Ramachandran Anbu Lenin Kulandaivel Poovizhi Inbasekaran Jayamani Baskaran Panneerselvam Periasamy |
| author_facet | Thamilselvi Ramachandran Anbu Lenin Kulandaivel Poovizhi Inbasekaran Jayamani Baskaran Panneerselvam Periasamy |
| author_sort | Thamilselvi Ramachandran |
| collection | DOAJ |
| description | Ovarian carcinosarcoma (MMMT—malignant mixed Müllerian tumors) is highly aggressive, rare tumor, affecting postmenopausal women with the incidence peak in the sixth decade with significant morbidity and mortality. Uterine carcinosarcomas are rare tumors comprising less than 5% of uterine malignancies. Ovarian cancer is the seventh cause of death and morbidity in females worldwide.To study about the clinical, morphological, and immunohistochemical study of case series of ovarian and uterine carcinosarcoma. Retrospective study of three cases. In first case a 50-year-old woman presented with a left ovarian tumor with a clinical diagnosis of carcinoma of ovary, USG-malignant ovarian tumor. Cancer antigen-125 (Ca-125) was elevated. She underwent surgery and final diagnosis was ovarian carcinosarcoma with high-grade papillary serous carcinoma of endometrium. In second case a 56-year-old woman presented with mass descending per vaginum—three years, abdominal pain—three months. Clinical diagnosis of malignant tumor of the right ovary was made. Ca-125 was elevated. She underwent surgery and the final diagnosis was right ovarian carcinosarcoma with a heterologous component and omental metastatic deposit. In third case a 48-year-old woman presented with continuous bleeding per vaginum for two months. Diagnosed as abnormal uterine bleeding— leiomyoma. She underwent panhysterectomy with lymph nodes removal and final diagnosis was uterine carcinosarcoma. Ovarian carcinosarcomas are very aggressive tumors that are usually diagnosed at an advanced stage due to its asymptomatic nature, its lack of active screening, and early detection techniques. The survival rate after diagnosis varies by stage of disease and uterine and ovarian carcinosarcomas.er horizons involving younger patients with asymptomatic severe AS, and long term outcomes of valve durability and moderate AS in combination with cardiac failure bicuspid aortic valve stenosis and pure native aortic regurgitation are however still under research. |
| format | Article |
| id | doaj-art-5bb6301d5713414980e51933a4d1ccdc |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-5bb6301d5713414980e51933a4d1ccdc2025-08-20T03:31:36ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S2021S202410.4103/jpbs.jpbs_1658_24Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case SeriesThamilselvi RamachandranAnbu Lenin KulandaivelPoovizhi InbasekaranJayamani BaskaranPanneerselvam PeriasamyOvarian carcinosarcoma (MMMT—malignant mixed Müllerian tumors) is highly aggressive, rare tumor, affecting postmenopausal women with the incidence peak in the sixth decade with significant morbidity and mortality. Uterine carcinosarcomas are rare tumors comprising less than 5% of uterine malignancies. Ovarian cancer is the seventh cause of death and morbidity in females worldwide.To study about the clinical, morphological, and immunohistochemical study of case series of ovarian and uterine carcinosarcoma. Retrospective study of three cases. In first case a 50-year-old woman presented with a left ovarian tumor with a clinical diagnosis of carcinoma of ovary, USG-malignant ovarian tumor. Cancer antigen-125 (Ca-125) was elevated. She underwent surgery and final diagnosis was ovarian carcinosarcoma with high-grade papillary serous carcinoma of endometrium. In second case a 56-year-old woman presented with mass descending per vaginum—three years, abdominal pain—three months. Clinical diagnosis of malignant tumor of the right ovary was made. Ca-125 was elevated. She underwent surgery and the final diagnosis was right ovarian carcinosarcoma with a heterologous component and omental metastatic deposit. In third case a 48-year-old woman presented with continuous bleeding per vaginum for two months. Diagnosed as abnormal uterine bleeding— leiomyoma. She underwent panhysterectomy with lymph nodes removal and final diagnosis was uterine carcinosarcoma. Ovarian carcinosarcomas are very aggressive tumors that are usually diagnosed at an advanced stage due to its asymptomatic nature, its lack of active screening, and early detection techniques. The survival rate after diagnosis varies by stage of disease and uterine and ovarian carcinosarcomas.er horizons involving younger patients with asymptomatic severe AS, and long term outcomes of valve durability and moderate AS in combination with cardiac failure bicuspid aortic valve stenosis and pure native aortic regurgitation are however still under research.https://journals.lww.com/10.4103/jpbs.jpbs_1658_24lymphadenectomy and chemotherapyomentectomyuterine and ovarian carcinosarcoma |
| spellingShingle | Thamilselvi Ramachandran Anbu Lenin Kulandaivel Poovizhi Inbasekaran Jayamani Baskaran Panneerselvam Periasamy Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series Journal of Pharmacy and Bioallied Sciences lymphadenectomy and chemotherapy omentectomy uterine and ovarian carcinosarcoma |
| title | Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series |
| title_full | Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series |
| title_fullStr | Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series |
| title_full_unstemmed | Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series |
| title_short | Carcinosarcoma of Uterus and Ovary—Clinical, Morphological, and Immunohistochemical Study of Case Series |
| title_sort | carcinosarcoma of uterus and ovary clinical morphological and immunohistochemical study of case series |
| topic | lymphadenectomy and chemotherapy omentectomy uterine and ovarian carcinosarcoma |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1658_24 |
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