An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study
Introduction: The role of bacteria in the pathogenesis of periodontitis, pericoronitis, and periapical infections has been well-established. However, the variation in the severity and prognosis of these lesions could suggest a potential role of other microorganisms, such as viruses and fungi. This...
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The Journal of Infection in Developing Countries
2022-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17358 |
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| author | Wael Khalil Hani Abd-Ul-Salam Abd El Hadi Kanj Rémi Safi Mohammad El-Harakeh Mazen Kurban Elias A Rahal Ghassan M Matar |
| author_facet | Wael Khalil Hani Abd-Ul-Salam Abd El Hadi Kanj Rémi Safi Mohammad El-Harakeh Mazen Kurban Elias A Rahal Ghassan M Matar |
| author_sort | Wael Khalil |
| collection | DOAJ |
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Introduction: The role of bacteria in the pathogenesis of periodontitis, pericoronitis, and periapical infections has been well-established. However, the variation in the severity and prognosis of these lesions could suggest a potential role of other microorganisms, such as viruses and fungi. This study aims to evaluate the presence of adenovirus, human papillomavirus-16, Epstein-Barr virus, Candida, and non-Candida fungi in these infections.
Methodology: A cross-sectional study including 120 healthy adult patients presenting with dental infections requiring dental extractions were conducted to assess the prevalence and the relative quantity of viruses and fungi in saliva, infected, and healthy tissues using quantitative polymerase chain reaction tests. Samples were collected, and a categorical scale was used for the prevalence and a continuous scale for the relative quantification. Statistical analyses were performed using Chi-square for the prevalence and Wilcoxon rank test for the relative quantification.
Results: Except for the Epstein-Barr virus and Candida, the presence of viruses and fungi was significantly associated with dental infections. Adenovirus showed an association with pericoronitis, while human papilloma virus-16 exhibited an association with periapical infections. Non-Candida fungi, on the other hand, showed a positive association with all infected tissues and saliva as compared to healthy control lesions except for periapical infections.
Conclusions: According to this study, viruses and fungi were found to be prevalent in dental infections. However, their associations with those infections vary depending on the types of viruses or fungi involved and the category of dental infections.
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| format | Article |
| id | doaj-art-5bb5e26410a74d828ffe5b56f05e03d3 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-5bb5e26410a74d828ffe5b56f05e03d32025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-12-01161210.3855/jidc.17358An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional studyWael Khalil0Hani Abd-Ul-Salam1Abd El Hadi Kanj2Rémi Safi3Mohammad El-Harakeh4Mazen Kurban5Elias A Rahal6Ghassan M Matar7Department of Experimental Pathology, Immunology, and Microbiology, Center for Infectious Diseases Research, WHO Collaborating Center for Reference and Research on Bacterial Pathogens, Faculty of Medicine, American University of Beirut, Beirut, LebanonFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, CanadaDepartment of Orthodontics, College of Dentistry, Al-Ayen University, Thi-Qar, IraqDepartment of Dermatology, American University of Beirut Medical Center, Beirut, LebanonDepartment of Dermatology, American University of Beirut Medical Center, Beirut, LebanonDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut, LebanonDepartment of Experimental Pathology, Immunology, and Microbiology, Center for Infectious Diseases Research, WHO Collaborating Center for Reference and Research on Bacterial Pathogens, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Experimental Pathology, Immunology, and Microbiology, Center for Infectious Diseases Research, WHO Collaborating Center for Reference and Research on Bacterial Pathogens, Faculty of Medicine, American University of Beirut, Beirut, Lebanon Introduction: The role of bacteria in the pathogenesis of periodontitis, pericoronitis, and periapical infections has been well-established. However, the variation in the severity and prognosis of these lesions could suggest a potential role of other microorganisms, such as viruses and fungi. This study aims to evaluate the presence of adenovirus, human papillomavirus-16, Epstein-Barr virus, Candida, and non-Candida fungi in these infections. Methodology: A cross-sectional study including 120 healthy adult patients presenting with dental infections requiring dental extractions were conducted to assess the prevalence and the relative quantity of viruses and fungi in saliva, infected, and healthy tissues using quantitative polymerase chain reaction tests. Samples were collected, and a categorical scale was used for the prevalence and a continuous scale for the relative quantification. Statistical analyses were performed using Chi-square for the prevalence and Wilcoxon rank test for the relative quantification. Results: Except for the Epstein-Barr virus and Candida, the presence of viruses and fungi was significantly associated with dental infections. Adenovirus showed an association with pericoronitis, while human papilloma virus-16 exhibited an association with periapical infections. Non-Candida fungi, on the other hand, showed a positive association with all infected tissues and saliva as compared to healthy control lesions except for periapical infections. Conclusions: According to this study, viruses and fungi were found to be prevalent in dental infections. However, their associations with those infections vary depending on the types of viruses or fungi involved and the category of dental infections. https://jidc.org/index.php/journal/article/view/17358PeriodontitispericoronitisPCRmicrobiologyvirusfungi |
| spellingShingle | Wael Khalil Hani Abd-Ul-Salam Abd El Hadi Kanj Rémi Safi Mohammad El-Harakeh Mazen Kurban Elias A Rahal Ghassan M Matar An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study Journal of Infection in Developing Countries Periodontitis pericoronitis PCR microbiology virus fungi |
| title | An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study |
| title_full | An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study |
| title_fullStr | An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study |
| title_full_unstemmed | An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study |
| title_short | An evaluation of an array of viruses and fungi in adult Lebanese patients presenting with various dental infections: A cross-sectional study |
| title_sort | evaluation of an array of viruses and fungi in adult lebanese patients presenting with various dental infections a cross sectional study |
| topic | Periodontitis pericoronitis PCR microbiology virus fungi |
| url | https://jidc.org/index.php/journal/article/view/17358 |
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