Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.

Within the first three weeks of human immunodeficiency virus (HIV) infection, virus replication peaks in peripheral blood. Despite the critical, causal role of virus replication in determining transmissibility and kinetics of progression to acquired immune deficiency syndrome (AIDS), there is limite...

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Main Authors: Adam J Ericsen, Michael Lauck, Mariel S Mohns, Sarah R DiNapoli, James P Mutschler, Justin M Greene, Jason T Weinfurter, Gabrielle Lehrer-Brey, Trent M Prall, Samantha M Gieger, Connor R Buechler, Kristin A Crosno, Eric J Peterson, Matthew R Reynolds, Roger W Wiseman, Benjamin J Burwitz, Jacob D Estes, Jonah B Sacha, Thomas C Friedrich, Jason M Brenchley, David H O'Connor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006048&type=printable
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author Adam J Ericsen
Michael Lauck
Mariel S Mohns
Sarah R DiNapoli
James P Mutschler
Justin M Greene
Jason T Weinfurter
Gabrielle Lehrer-Brey
Trent M Prall
Samantha M Gieger
Connor R Buechler
Kristin A Crosno
Eric J Peterson
Matthew R Reynolds
Roger W Wiseman
Benjamin J Burwitz
Jacob D Estes
Jonah B Sacha
Thomas C Friedrich
Jason M Brenchley
David H O'Connor
author_facet Adam J Ericsen
Michael Lauck
Mariel S Mohns
Sarah R DiNapoli
James P Mutschler
Justin M Greene
Jason T Weinfurter
Gabrielle Lehrer-Brey
Trent M Prall
Samantha M Gieger
Connor R Buechler
Kristin A Crosno
Eric J Peterson
Matthew R Reynolds
Roger W Wiseman
Benjamin J Burwitz
Jacob D Estes
Jonah B Sacha
Thomas C Friedrich
Jason M Brenchley
David H O'Connor
author_sort Adam J Ericsen
collection DOAJ
description Within the first three weeks of human immunodeficiency virus (HIV) infection, virus replication peaks in peripheral blood. Despite the critical, causal role of virus replication in determining transmissibility and kinetics of progression to acquired immune deficiency syndrome (AIDS), there is limited understanding of the conditions required to transform the small localized transmitted founder virus population into a large and heterogeneous systemic infection. Here we show that during the hyperacute "pre-peak" phase of simian immunodeficiency virus (SIV) infection in macaques, high levels of microbial DNA transiently translocate into peripheral blood. This, heretofore unappreciated, hyperacute-phase microbial translocation was accompanied by sustained reduction of lipopolysaccharide (LPS)-specific antibody titer, intestinal permeability, increased abundance of CD4+CCR5+ T cell targets of virus replication, and T cell activation. To test whether increasing gastrointestinal permeability to cause microbial translocation would amplify viremia, we treated two SIV-infected macaque 'elite controllers' with a short-course of dextran sulfate sodium (DSS)-stimulating a transient increase in microbial translocation and a prolonged recrudescent viremia. Altogether, our data implicates translocating microbes as amplifiers of immunodeficiency virus replication that effectively undermine the host's capacity to contain infection.
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issn 1553-7366
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publisher Public Library of Science (PLoS)
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spelling doaj-art-5bb5366dcfb14baa9fa9ff8b612eae342025-08-20T02:03:19ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742016-12-011212e100604810.1371/journal.ppat.1006048Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.Adam J EricsenMichael LauckMariel S MohnsSarah R DiNapoliJames P MutschlerJustin M GreeneJason T WeinfurterGabrielle Lehrer-BreyTrent M PrallSamantha M GiegerConnor R BuechlerKristin A CrosnoEric J PetersonMatthew R ReynoldsRoger W WisemanBenjamin J BurwitzJacob D EstesJonah B SachaThomas C FriedrichJason M BrenchleyDavid H O'ConnorWithin the first three weeks of human immunodeficiency virus (HIV) infection, virus replication peaks in peripheral blood. Despite the critical, causal role of virus replication in determining transmissibility and kinetics of progression to acquired immune deficiency syndrome (AIDS), there is limited understanding of the conditions required to transform the small localized transmitted founder virus population into a large and heterogeneous systemic infection. Here we show that during the hyperacute "pre-peak" phase of simian immunodeficiency virus (SIV) infection in macaques, high levels of microbial DNA transiently translocate into peripheral blood. This, heretofore unappreciated, hyperacute-phase microbial translocation was accompanied by sustained reduction of lipopolysaccharide (LPS)-specific antibody titer, intestinal permeability, increased abundance of CD4+CCR5+ T cell targets of virus replication, and T cell activation. To test whether increasing gastrointestinal permeability to cause microbial translocation would amplify viremia, we treated two SIV-infected macaque 'elite controllers' with a short-course of dextran sulfate sodium (DSS)-stimulating a transient increase in microbial translocation and a prolonged recrudescent viremia. Altogether, our data implicates translocating microbes as amplifiers of immunodeficiency virus replication that effectively undermine the host's capacity to contain infection.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006048&type=printable
spellingShingle Adam J Ericsen
Michael Lauck
Mariel S Mohns
Sarah R DiNapoli
James P Mutschler
Justin M Greene
Jason T Weinfurter
Gabrielle Lehrer-Brey
Trent M Prall
Samantha M Gieger
Connor R Buechler
Kristin A Crosno
Eric J Peterson
Matthew R Reynolds
Roger W Wiseman
Benjamin J Burwitz
Jacob D Estes
Jonah B Sacha
Thomas C Friedrich
Jason M Brenchley
David H O'Connor
Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.
PLoS Pathogens
title Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.
title_full Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.
title_fullStr Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.
title_full_unstemmed Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.
title_short Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.
title_sort microbial translocation and inflammation occur in hyperacute immunodeficiency virus infection and compromise host control of virus replication
url https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006048&type=printable
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