Design, Synthesis and Molecular Modeling of Pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives as Dual Inhibitors of CDK2 and TRKA Kinases with Antiproliferative Activity

Design, Synthesis and Molecular Modeling of Pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives as Dual Inhibitors of CDK2 and TRKA Kinases with Antiproliferative Activity

Background: The increasing prevalence of drug resistance in cancer therapy underscores the urgent need for novel therapeutic approaches. Dual enzyme inhibitors, targeting critical kinases such as CDK2 and TRKA, represent a promising strategy. The goal of this investigation was to design, synthesize,...

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Bibliographic Details
Main Authors: Mohamed H. Attia, Deena S. Lasheen, Nermin Samir, Azza T. Taher, Hatem A. Abdel-Aziz, Dalal A. Abou El Ella
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
synthesis
pyrazolo[1,5-<i>a</i>]pyrimidine
anticancer activity
TRKA
CDK2
Online Access:https://www.mdpi.com/1424-8247/17/12/1667
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