Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes
The emergence of antimicrobial resistance (AMR) in pathogens transmitted through food poses a significant threat to global public health, complicating infection treatment and increasing mortality rates. This review explores the role of resistome mapping as a crucial tool for understanding the transm...
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| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Applied Microbiology |
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| Online Access: | https://www.mdpi.com/2673-8007/4/4/102 |
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| author | Muneer Oladipupo Yaqub Chinedu Eucharia Joseph Aashika Jain Lekshmi K. Edison |
| author_facet | Muneer Oladipupo Yaqub Chinedu Eucharia Joseph Aashika Jain Lekshmi K. Edison |
| author_sort | Muneer Oladipupo Yaqub |
| collection | DOAJ |
| description | The emergence of antimicrobial resistance (AMR) in pathogens transmitted through food poses a significant threat to global public health, complicating infection treatment and increasing mortality rates. This review explores the role of resistome mapping as a crucial tool for understanding the transmission dynamics of antimicrobial resistance genes (ARGs) in foodborne pathogens, such as <i>Salmonella</i>, <i>Escherichia coli</i>, <i>Listeria monocytogenes</i>, and <i>Campylobacter</i> spp., as well as various techniques for resistome mapping, such as metagenomic sequencing, PCR-based methods, and whole-genome sequencing (WGS), highlighting the significance of horizontal gene transfer (HGT) as a key mechanism for ARG dissemination in foodborne pathogens. Additionally, we investigated the influence of agricultural practices and environmental factors on AMR development, highlighting the critical need for improved surveillance, antibiotic stewardship, and global collaboration to mitigate the spread of resistant ARGs through the food chain. The perceptions gained from resistome mapping play an essential role in developing effective approaches to address AMR and to ensure food safety. |
| format | Article |
| id | doaj-art-5bb1036becfa49a19707c06d5133b1ca |
| institution | DOAJ |
| issn | 2673-8007 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Microbiology |
| spelling | doaj-art-5bb1036becfa49a19707c06d5133b1ca2025-08-20T02:55:31ZengMDPI AGApplied Microbiology2673-80072024-10-01441476149210.3390/applmicrobiol4040102Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance GenesMuneer Oladipupo Yaqub0Chinedu Eucharia Joseph1Aashika Jain2Lekshmi K. Edison3Department of Biological Sciences, School of Natural Science and Mathematics, University of Texas at Dallas, Richardson, TX 75080, USAMicrobiology Laboratory, Department of Microbiology and Parasitology, Benue State University Teaching Hospital, Makurdi, Benue 970101, NigeriaDepartment of Microbiology, The Oxford College of Science, Bangalore University, Bangalore, Karnataka 560102, IndiaDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USAThe emergence of antimicrobial resistance (AMR) in pathogens transmitted through food poses a significant threat to global public health, complicating infection treatment and increasing mortality rates. This review explores the role of resistome mapping as a crucial tool for understanding the transmission dynamics of antimicrobial resistance genes (ARGs) in foodborne pathogens, such as <i>Salmonella</i>, <i>Escherichia coli</i>, <i>Listeria monocytogenes</i>, and <i>Campylobacter</i> spp., as well as various techniques for resistome mapping, such as metagenomic sequencing, PCR-based methods, and whole-genome sequencing (WGS), highlighting the significance of horizontal gene transfer (HGT) as a key mechanism for ARG dissemination in foodborne pathogens. Additionally, we investigated the influence of agricultural practices and environmental factors on AMR development, highlighting the critical need for improved surveillance, antibiotic stewardship, and global collaboration to mitigate the spread of resistant ARGs through the food chain. The perceptions gained from resistome mapping play an essential role in developing effective approaches to address AMR and to ensure food safety.https://www.mdpi.com/2673-8007/4/4/102antibiotic resistance genes (ARGs)horizontal gene transfer (HGT)metagenome sequencingwhole-genome sequencingantibiotic stewardshipfood safety |
| spellingShingle | Muneer Oladipupo Yaqub Chinedu Eucharia Joseph Aashika Jain Lekshmi K. Edison Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes Applied Microbiology antibiotic resistance genes (ARGs) horizontal gene transfer (HGT) metagenome sequencing whole-genome sequencing antibiotic stewardship food safety |
| title | Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes |
| title_full | Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes |
| title_fullStr | Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes |
| title_full_unstemmed | Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes |
| title_short | Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes |
| title_sort | resistome mapping in foodborne pathogens understanding role in the transmission dynamics of resistance genes |
| topic | antibiotic resistance genes (ARGs) horizontal gene transfer (HGT) metagenome sequencing whole-genome sequencing antibiotic stewardship food safety |
| url | https://www.mdpi.com/2673-8007/4/4/102 |
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