Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye
PurposeThe goal of the study is to introduce a generic, versatile biomechanical model that aims to reproduce the dynamic wobbling phenomenon.MethodsA systematic strategy is used, which includes a) capturing the in vivo data on a group of healthy volunteers, b) analyzing the changes in Purkinje image...
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| Format: | Article |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1504769/full |
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| author | Ali Dahaghin Milad Salimibani Agnieszka Boszczyk Agnieszka Jóźwik Jorge Grasa Jorge Grasa Joanna Przeździecka-Dołyk Joanna Przeździecka-Dołyk Joanna Przeździecka-Dołyk Damian Siedlecki |
| author_facet | Ali Dahaghin Milad Salimibani Agnieszka Boszczyk Agnieszka Jóźwik Jorge Grasa Jorge Grasa Joanna Przeździecka-Dołyk Joanna Przeździecka-Dołyk Joanna Przeździecka-Dołyk Damian Siedlecki |
| author_sort | Ali Dahaghin |
| collection | DOAJ |
| description | PurposeThe goal of the study is to introduce a generic, versatile biomechanical model that aims to reproduce the dynamic wobbling phenomenon.MethodsA systematic strategy is used, which includes a) capturing the in vivo data on a group of healthy volunteers, b) analyzing the changes in Purkinje images over time, and c) performing the combined biomechanical and optical simulations to develop the model that might be useful for understanding the mechanical behavior of the lens during wobbling and its influence on ocular dynamics.ResultsExamples of lens wobbling patterns for six measured eyes were presented, and parameters characterizing the oscillatory motion were determined, including frequency of oscillations, Q-factor, damping factor and time constant. The average values of these parameters are the following: frequency: 20.0 ± 2.4 Hz; Q-factor: 1.86 ± 0.44; damping factor: 0.27 ± 0.06; time constant: 0.11 ± 0.06 s. The data reproduced by means of simulations: frequency: 19.3 Hz; Q-factor: 2.17; damping factor: 0.23; time constant: 0.15 s. This comparison reveals a good agreement between the measured and reconstructed data with the values being within the standard deviation limits.ConclusionThe developed generic model together with the presented methodology is able to reconstruct the typical crystalline lens wobbling dynamics with a satisfying accuracy. However, the observed intersubject variability highlights the need for personalized biomechanical models. The introduced model may constitute the basis for future individualization of the data, bringing broad perspectives for prospective investigations aimed to explain the biomechanical mechanisms within the eye. |
| format | Article |
| id | doaj-art-5bb00830ce9547e39f3d1db0f815fdc1 |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-5bb00830ce9547e39f3d1db0f815fdc12025-08-20T02:02:01ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-03-011310.3389/fbioe.2025.15047691504769Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eyeAli Dahaghin0Milad Salimibani1Agnieszka Boszczyk2Agnieszka Jóźwik3Jorge Grasa4Jorge Grasa5Joanna Przeździecka-Dołyk6Joanna Przeździecka-Dołyk7Joanna Przeździecka-Dołyk8Damian Siedlecki9Department of Optics and Photonics, Wroclaw University of Science and Technology, Wrocław, PolandDepartment of Optics and Photonics, Wroclaw University of Science and Technology, Wrocław, PolandDepartment of Optics and Photonics, Wroclaw University of Science and Technology, Wrocław, PolandDepartment of Optics and Photonics, Wroclaw University of Science and Technology, Wrocław, PolandAragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, SpainDeanery of Clinical Sciences, University of Edinburgh, Edinburgh, United KingdomDepartment and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, PolandCREO Research and Development Centre SPEKTRUM Clinical Ophthalmic Center, Wroclaw, PolandDepartment of Optics and Photonics, Wroclaw University of Science and Technology, Wrocław, PolandPurposeThe goal of the study is to introduce a generic, versatile biomechanical model that aims to reproduce the dynamic wobbling phenomenon.MethodsA systematic strategy is used, which includes a) capturing the in vivo data on a group of healthy volunteers, b) analyzing the changes in Purkinje images over time, and c) performing the combined biomechanical and optical simulations to develop the model that might be useful for understanding the mechanical behavior of the lens during wobbling and its influence on ocular dynamics.ResultsExamples of lens wobbling patterns for six measured eyes were presented, and parameters characterizing the oscillatory motion were determined, including frequency of oscillations, Q-factor, damping factor and time constant. The average values of these parameters are the following: frequency: 20.0 ± 2.4 Hz; Q-factor: 1.86 ± 0.44; damping factor: 0.27 ± 0.06; time constant: 0.11 ± 0.06 s. The data reproduced by means of simulations: frequency: 19.3 Hz; Q-factor: 2.17; damping factor: 0.23; time constant: 0.15 s. This comparison reveals a good agreement between the measured and reconstructed data with the values being within the standard deviation limits.ConclusionThe developed generic model together with the presented methodology is able to reconstruct the typical crystalline lens wobbling dynamics with a satisfying accuracy. However, the observed intersubject variability highlights the need for personalized biomechanical models. The introduced model may constitute the basis for future individualization of the data, bringing broad perspectives for prospective investigations aimed to explain the biomechanical mechanisms within the eye.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1504769/fullin vivo crystalline lens oscillationslens inertial motionlens wobblingfinite element methodPurkinje imagingocular biomechanics |
| spellingShingle | Ali Dahaghin Milad Salimibani Agnieszka Boszczyk Agnieszka Jóźwik Jorge Grasa Jorge Grasa Joanna Przeździecka-Dołyk Joanna Przeździecka-Dołyk Joanna Przeździecka-Dołyk Damian Siedlecki Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye Frontiers in Bioengineering and Biotechnology in vivo crystalline lens oscillations lens inertial motion lens wobbling finite element method Purkinje imaging ocular biomechanics |
| title | Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye |
| title_full | Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye |
| title_fullStr | Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye |
| title_full_unstemmed | Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye |
| title_short | Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye |
| title_sort | biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye |
| topic | in vivo crystalline lens oscillations lens inertial motion lens wobbling finite element method Purkinje imaging ocular biomechanics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1504769/full |
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